ArticleThe Journal of allergy and clinical immunology2019
Rhinitis in children and adolescents with asthma: Ubiquitous, difficult to control, and associated with asthma outcomes.
Article in The Journal of allergy and clinical immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed, 1 synthesis or guideline pooled it, 73 citations in OpenAlex.
- Association Between Mouth Breathing and Asthma: a Systematic Review and Meta-analysis.Current allergy and asthma reports · 2020Pooled it
- Evolution of IgE sensitization profiles toThe World Allergy Organization journal · 2026Article
- Exposure to Urinary and Dust Parabens: Compound-Specific Risks for Pediatric Respiratory Allergic Phenotypes.Toxics · 2026Article
- Diagnostic Utility of Serum Specific IgE for Indoor Aeroallergen Sensitization in Indian Children (5-15 years) with Allergic Rhinitis and Asthma: Correspondence.Indian journal of pediatrics · 2026Article
- Rhinoconjunctivitis symptoms in children and adolescents with asthma: Longitudinal clustering analysis.The Journal of allergy and clinical immunology · 2025Article
- Polymerized Molecular Allergoid Alt a1: Effective SCIT in Pediatric Asthma Patients.Journal of clinical medicine · 2025Article
- Clinical and molecular analysis of longitudinal rhinitis phenotypes in an urban birth cohort.The Journal of allergy and clinical immunology · 2025Article
- Application of fractional exhaled nitric oxide and nasal nitric oxide in the evaluation of asthma control.Frontiers in pediatrics · 2025Article
- Comorbid asthma is associated with rhinitis severity in children exposed to air pollutants.Pediatric research · 2024Article
- Comparative analysis of masseter muscle electrical activity by nasal patency in children with rhinitis and asthma: a pilot observational study.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2024Observational
- IL-1β and iNOS can drive the asthmatic comorbidities and decrease of lung function in perennial allergic rhinitis children.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2024Article
- The Link between Periodontal Disease and Asthma: How Do These Two Diseases Affect Each Other?Journal of clinical medicine · 2023Review
- [The need for an integrated approach to rhinitis and asthma]Revista de la Facultad de Ciencias Medicas (Cordoba, Argentina) · 2023Article
- Racial and Ethnic Disparities in Allergen Immunotherapy Prescription for Allergic Rhinitis.The journal of allergy and clinical immunology. In practice · 2023Article
- Allergic rhinitis co-morbidity on asthma outcomes in city school children.The Journal of asthma : official journal of the Association for the Care of Asthma · 2023Article
- Treatment with pollen allergen immunotherapy improves health-related quality of life in children and adolescents: a three-year follow-up-study.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2023Article
- Risk Assessment of Allergic Diseases Among Preschool Children in Guangzhou, China: A Cross-Sectional Study.Journal of asthma and allergy · 2023Article
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- Associations of early-life factors and indoor environmental exposure with asthma among children: a case-control study in Chongqing, China.World journal of pediatrics : WJP · 2022Article
- The Role of Comorbidities in Difficult-to-Control Asthma in Adults and Children.The journal of allergy and clinical immunology. In practice · 2022Article
Corrections and comments
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Authors and funding
19 authors at 11 institutions in 1 country.
Funding
Abstract
backgroundRhinitis and asthma are linked, but substantial knowledge gaps in this relationship exist.
objectiveWe sought to determine the prevalence of rhinitis and its phenotypes in children and adolescents with asthma, assess symptom severity and medication requirements for rhinitis control, and investigate associations between rhinitis and asthma.
methodsSeven hundred forty-nine children with asthma participating in the Asthma Phenotypes in the Inner-City study received baseline evaluations and were managed for 1 year with algorithm-based treatments for rhinitis and asthma. Rhinitis was diagnosed by using a questionnaire focusing on individual symptoms, and predefined phenotypes were determined by combining symptom patterns with skin tests and measurement of serum specific IgE levels.
resultsAnalyses were done on 619 children with asthma who completed at least 4 of 6 visits. Rhinitis was present in 93.5%, and phenotypes identified at baseline were confirmed during the observation/management year. Perennial allergic rhinitis with seasonal exacerbations was most common (34.2%) and severe. Nonallergic rhinitis was least common (11.3%) and least severe. The majority of children remained symptomatic despite use of nasal corticosteroids with or without oral antihistamines. Rhinitis was worse in patients with difficult-to-control versus easy-to-control asthma, and its seasonal patterns partially corresponded to those of difficult-to-control asthma.
conclusionRhinitis is almost ubiquitous in urban children with asthma, and its activity tracks that of lower airway disease. Perennial allergic rhinitis with seasonal exacerbations is the most severe phenotype and most likely to be associated with difficult-to-control asthma. This study offers strong support to the concept that rhinitis and asthma represent the manifestations of 1 disease in 2 parts of the airways.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.