ArticleAlcohol (Fayetteville, N.Y.)2019
Alcohol consumption increases susceptibility to pneumococcal pneumonia in a humanized murine HIV model mediated by intestinal dysbiosis.
Article in Alcohol (Fayetteville, N.Y.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.
- Alcohol's Effects on the Lung and Lung Disease.Alcohol research : current reviews · 2025Pooled it
- Gut-immune-PVAT axis is involved in ethanol-induced abdominal aortic dysfunction via IL-17RA, TLR4, and FPR1 signaling.Gut microbes · 2026Article
- Pioglitazone Reverses Alcohol-induced Human Immunodeficiency Virus (HIV) Replication and IL-1β Expression in Alveolar Macrophages.American journal of respiratory cell and molecular biology · 2025Article
- The alcohol exposome.Alcohol (Fayetteville, N.Y.) · 2025Review
- Effects of alcohol on the composition and metabolism of the intestinal microbiota among people with HIV: A cross-sectional study.Alcohol (Fayetteville, N.Y.) · 2024Article
- Natural killer cell effector function is critical for host defense against alcohol-associated bacterial pneumonia.NPJ biofilms and microbiomes · 2024Article
- Regulation of Natural Killer Cell TGF-β and AhR Signaling Pathways Via the Intestinal Microbiota is Critical for Host Defense Against Alcohol-Associated Bacterial Pneumonia.Research square · 2023Article
- Article
- Explaining the perspective of people living with HIV on health-promoting behaviours based on Pender's model: A directed content analysis.Nursing open · 2023Article
- The Inherited Intestinal Microbiota from Myeloid-Specific ZIP8KO Mice Impairs Pulmonary Host Defense against Pneumococcal Pneumonia.Pathogens (Basel, Switzerland) · 2023Article
- Gut Microbiota Protected AgainstFrontiers in cellular and infection microbiology · 2022Article
- Drugs of Abuse and Their Impact on Viral Pathogenesis.Viruses · 2021Review
- The Spanish gut microbiome reveals links between microorganisms and Mediterranean diet.Scientific reports · 2021Article
- Alcohol-associated intestinal dysbiosis alters mucosal-associated invariant T-cell phenotype and function.Alcoholism, clinical and experimental research · 2021Article
- Alcohol use disorder: A pre-existing condition for COVID-19?Alcohol (Fayetteville, N.Y.) · 2021Review
- Alcohol Use and Abuse Conspires With HIV Infection to Aggravate Intestinal Dysbiosis and Increase Microbial Translocation in People Living With HIV: A Review.Frontiers in immunology · 2021Review
- A review of potential microbiome-gut-brain axis mediated neurocognitive conditions in persons living with HIV.Brain, behavior, & immunity - health · 2020Review
- Premises among SARS-CoV-2, dysbiosis and diarrhea: Walking through the ACE2/mTOR/autophagy route.Medical hypotheses · 2020Article
- Health related behaviors among HIV-infected people who are successfully linked to care: an institutional-based cross-sectional study.Infectious diseases of poverty · 2020Article
- Intestinal Microbial Products From Alcohol-Fed Mice Contribute to Intestinal Permeability and Peripheral Immune Activation.Alcoholism, clinical and experimental research · 2019Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
Abstract
Alcohol use in persons living with HIV (PLWH) worsens the severity of bacterial pneumonia. However, the exact mechanism(s) by which this occurs remain ill-defined. We hypothesized that alcohol in the setting of HIV infection decreases Streptococcus pneumoniae clearance from the lung through mechanisms mediated by the gut microbiota. Humanized BLT (bone marrow, liver, thymus) mice were infected with 1 × 10
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.