ArticleClinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association2019
Cortico-anorectal, Spino-anorectal, and Cortico-spinal Nerve Conduction and Locus of Neuronal Injury in Patients With Fecal Incontinence.
Article in Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07192328 (Randomized Cross-Over Dose-Efficacy Study of rTMS in Healthy Young Female Volunteers), which is not on this map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Randomized Cross-Over Dose-Efficacy Study of rTMS in Healthy Young Female Volunteers
Who cites it
10 citing papers in PubMed, 24 citations in OpenAlex.
- Frequency-Dependent Effects of Transcranial and Translumbosacral Magnetic Stimulation on Anorectal Neurophysiology: A Dose-Response Study in Healthy Women.Neurogastroenterology and motility · 2026Trial
- Effects of Translumbosacral Neuromodulation Therapy on Gut and Brain Interactions and Anorectal Neuropathy in Fecal Incontinence: A Randomized Study.Neuromodulation : journal of the International Neuromodulation Society · 2021Trial
- A Novel High-Density Electromyography Probe for Evaluating Anorectal Neurophysiology: Design, Human Feasibility Study, and Validation with Trans-Sacral Magnetic Stimulation.Annals of biomedical engineering · 2021Trial
- Randomised clinical trial: linaclotide vs placebo-a study of bi-directional gut and brain axis.Alimentary pharmacology & therapeutics · 2020Trial
- Electroceuticals and Magnetoceuticals in Gastroenterology.Biomolecules · 2024Review
- Faecal incontinence in adults.Nature reviews. Disease primers · 2022Review
- Translumbosacral Anorectal Magnetic Stimulation Test for Fecal Incontinence.Diseases of the colon and rectum · 2022Observational
- Epidemiologic Trends and Diagnostic Evaluation of Fecal Incontinence.Gastroenterology & hepatology · 2020Article
- A novel combined anorectal biofeedback and percutaneous tibial nerve stimulation protocol for treating fecal incontinence.Therapeutic advances in gastroenterology · 2020Article
- Current perspectives on the diagnosis and management of functional anorectal disorders in patients with inflammatory bowel disease.Therapeutic advances in gastroenterology · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 4 countries.
Funding
Abstract
BACKGROUND &
aimsThe neuropathophysiology of fecal incontinence (FI) is incompletely understood. We examined the efferent brain-anorectal and spino-anorectal motor-evoked potentials (MEP) to characterize the locus of neuronal injury in patients with FI.
methodsWe performed bilateral transcranial, translumbar, and transsacral magnetic stimulations in 27 patients with FI (19 female) and 31 healthy individuals (controls, 20 female) from 2015 through 2017. MEPs were recorded simultaneously from the rectum and anus using 4 ring electrodes. The difference in MEP latencies between the transcranial (TMS) and translumbar transsacral magnetic stimulations was calculated as cortico-spinal conduction time. MEP data were compared between patients with FI and controls. Patients filled out questionnaires that assessed the severity and effects of FI.
resultsThe MEP latencies with TMS were significantly longer in patients with FI than controls at most sites, and on both sides (P < .05). Almost all translumbar and transsacral MEP latencies were significantly prolonged in patients with FI vs controls (P < .01). The cortico-spinal conduction time were similar, on both sides, between patients with FI and controls. Ninety-three percent of patients had 1 or more abnormal translumbar and transsacral latencies, but neuropathy was patchy and variable, and not associated with sex or anal sphincter function or defects.
conclusionsPatients with FI have significant neuropathy that affects the cortico-anorectal and spino-anorectal efferent pathways. The primary loci are the lumbo-rectal, lumbo-anal, sacro-rectal, and sacro-anal nerves; the cortico-spinal segment appears intact. Peripheral spino-anal and spino-rectal neuropathy might therefore contribute to the pathogenesis of FI.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.