Evidence map›Paper›PMID 30213492›Full record

ArticlePlacenta2018

Macrophage- but not monocyte-derived extracellular vesicles induce placental pro-inflammatory responses.

Thomas F Rice, Beverly Donaldson, Marielle Bouqueau, Beate Kampmann, Beth Holder

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Placenta, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 28 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. Review
  9. Review
  10. Review
  11. Review
  12. Review
  13. Macrophage-Derived Extracellular Vesicles as Drug Delivery Systems for Triple Negative Breast Cancer (TNBC) Therapy.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2020
    Article
  14. Article
  15. Article
  16. Maternal Immunization: Nature Meets Nurture.Frontiers in microbiology · 2020
    Review
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Thomas F RiceSection of Paediatrics, Department of Medicine, Imperial College London, UK.
Beverly DonaldsonSection of Paediatrics, Department of Medicine, Imperial College London, UK.
Marielle BouqueauSection of Paediatrics, Department of Medicine, Imperial College London, UK.
Beate KampmannSection of Paediatrics, Department of Medicine, Imperial College London, UK; Vaccines & Immunity Theme, MRC Unit The Gambia at the London School of Hygiene and Tropical Medicine, Gambia; The Vaccine Centre, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK.
Beth HolderSection of Paediatrics, Department of Medicine, Imperial College London, UK; Vaccines & Immunity Theme, MRC Unit The Gambia at the London School of Hygiene and Tropical Medicine, Gambia. Electronic address: b.holder@imperial.ac.uk.
Imperial College London · GBMRC Unit the Gambia · GMUniversity of London · GB

Funding

MODULATION OF TROPHOBLAST DIFFERENTIATION AND FUNCTION BY IMMUNE CELL EXOSOMESR01HD093801 · NICHD · IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY AND MEDICINE · PI HOLDER, BETH · 2018 to 2022
$1.5M
Medical Research Council MC_UP_A900/1122Medical Research Council MC_UP_A900_1122NICHD NIH HHS R01 HD093801
6 · The paper itself

Abstract

The placenta sheds extracellular vesicles (EVs), including exosomes, into the maternal circulation. We recently demonstrated that this trafficking of EVs is bi-directional; with uptake of macrophage exosomes by the placenta inducing cytokine release. The specificity of this response is currently unknown. THP-1 cells were cultured as monocytes or differentiated to macrophages, and EVs isolated by ultra-centrifugation. The effect of EVs on human placental explants was measured by cytokine ELISA/luminex. Macrophage, but not monocyte, EVs induce the release of pro-inflammatory cytokines by the placenta. Thus, placental responses to immune cell EVs, including exosomes, reflects the phenotype of the source cell.

Indexed as

Cell LineExtracellular VesiclesFemaleHumansInflammationMacrophagesMonocytesPlacentaPregnancyCytokinesExosomesExplantsExtracellular vesiclesImmunologyMacrophagesReproductive immunologyTrophoblast

Identifiers

PMID30213492
PMCPMC6398160
OpenAlexW2883072314

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.