ArticleThe Journal of pediatrics2018
Cord Blood Metabolites Associated with Newborn Adiposity and Hyperinsulinemia.
Article in The Journal of pediatrics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 31 citations in OpenAlex.
- The Impact of Maternal Supplementation of Fish Oil and/or Probiotics During Pregnancy on the Serum Metabolomic Profile From Infancy to Childhood: Secondary Analysis of a Randomized Placebo-Controlled Trial.Current developments in nutrition · 2025Article
- Umbilical Cord Plasma Lysophospholipids and Triacylglycerols Associated with Birthweight Percentiles.Nutrients · 2024Article
- Myo-inositol alters the effects of glucose, leptin and insulin on placental palmitic acid and oleic acid metabolism.The Journal of physiology · 2023Article
- Early Life Origins of Cardio-Metabolic Outcomes in Boston Birth Cohort: Review of Findings and Future directions.Precision nutrition · 2023Article
- Associations of maternal plasma and umbilical cord plasma metabolomics profiles with birth anthropometric measures.Pediatric research · 2023Article
- Maternal and Cord Blood Serum Metabolite Associations with Childhood Adiposity and Body Composition Outcomes.Metabolites · 2023Article
- Cord Blood Plasma Metabolome-wide Associations With Height From Birth to Adolescence.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2023Article
- Fetal effects of mild maternal COVID-19 infection: metabolomic profiling of cord blood.Metabolomics : Official journal of the Metabolomic Society · 2023Article
- Article
- Childhood obesity and adverse cardiometabolic risk in large for gestational age infants and potential early preventive strategies: a narrative review.Pediatric research · 2022Review
- Network Approaches to Integrate Analyses of Genetics and Metabolomics Data with Applications to Fetal Programming Studies.Metabolites · 2022Article
- Metabolomic signatures of low- and high-adiposity neonates differ based on maternal BMI.American journal of physiology. Endocrinology and metabolism · 2022Article
- Improvement in Mung Bean Peptide on High-Fat Diet-Induced Insulin Resistance Mice Using Untargeted Serum Metabolomics.Frontiers in nutrition · 2022Article
- Metabolomics Applied to Cord Serum in Preeclampsia Newborns: Implications for Neonatal Outcomes.Frontiers in pediatrics · 2022Article
- Cord Blood Metabolome and BMI Trajectory from Birth to Adolescence: A Prospective Birth Cohort Study on Early Life Biomarkers of Persistent Obesity.Metabolites · 2021Article
- Associations of maternal bisphenol urine concentrations during pregnancy with neonatal metabolomic profiles.Metabolomics : Official journal of the Metabolomic Society · 2021Article
- Review
- Review
- Sex differences in infant blood metabolite profile in association with weight and adiposity measures.Pediatric research · 2020Article
- Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveTo evaluate the association between cord blood amino acid and acylcarnitine profiles and measures of adiposity and hyperinsulinemia in healthy newborns. STUDY
designA cross-sectional study of 118 full-term infants born to mothers without gestational diabetes was performed. Cord blood leptin, C-peptide, acylcarnitine, and amino acid levels were measured. Body composition was measured by air displacement plethysmography. Multivariate linear regression and principal component analysis were used to analyze associations of cord blood metabolites with newborn anthropometrics, leptin, and C-peptide.
resultsAcylcarnitines AC C2, AC C4-DC/Ci4-DC, and AC C8:1-OH/C6:1-DC were positively associated with leptin, and AC C14, AC C14:2, AC C16, AC C18, and AC C18:2 were negatively associated with C-peptide (P ≤ .0016). Principal component analysis revealed a positive association between factor 1(AC C2, AC C3, AC C5, AC C4/Ci4, AC C4-OH, AC C4-DC/Ci4-DC, glutamate/glutamine, and glycine) and adiposity measures.
conclusionsThe positive association of AC C2 and AC C4-DC/Ci4-DC levels with leptin may reflect excess fat stores, higher fatty acid oxidation rate, and mitochondrial dysfunction leading to accumulation of acylcarnitine intermediates. Principal component analysis revealed a positive association between branched chain amino acid and ketone body metabolites and adiposity, confirming prior findings in adults. Cord blood acylcarnitine profiles may identify at-risk children before obesity or insulin resistance develops.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.