Evidence map›Paper›PMID 30213439›Full record

ArticleTrends in pharmacological sciences2018

Pulmonary Ionocytes Challenge the Paradigm in Cystic Fibrosis.

Finn J Hawkins, Darrell N Kotton

Abstract readComment
PubMed Publisher
In one paragraph

Article in Trends in pharmacological sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Basic Science Perspective on Engineering and Modeling the Large Airways.Advances in experimental medicine and biology · 2023
    Article
  3. Revisiting CFTR Interactions: Old Partners and New Players.International journal of molecular sciences · 2021
    Review
  4. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Finn J HawkinsCenter for Regenerative Medicine of Boston University and Boston Medical Center, Boston, MA, USA; The Pulmonary Center, Boston University School of Medicine, Boston, MA, USA. Electronic address: hawk@bu.edu.
Darrell N KottonCenter for Regenerative Medicine of Boston University and Boston Medical Center, Boston, MA, USA; The Pulmonary Center, Boston University School of Medicine, Boston, MA, USA.
Boston Medical Center · US

Funding

iPSC-Derived Airway Basal Cells to Model Human Airway Development and DiseaseR01HL139799 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI HAWKINS, FINN · 2018 to 2022
$2.1M
NHLBI NIH HHS R01 HL139799
6 · The paper itself

Abstract

Two recent studies have identified novel airway cells termed pulmonary ionocytes that express higher levels of CFTR than other airway cells express. These findings raise new questions in the evolving debate about the physiological role of CFTR in lung epithelia and its importance in the pathogenesis of cystic fibrosis (CF).

Indexed as

Cystic FibrosisCystic Fibrosis Transmembrane Conductance RegulatorEpitheliumHumansLungCystic Fibrosis Transmembrane Conductance RegulatorairwayCFTRcystic fibrosisionocytelung

Identifiers

PMID30213439
OpenAlexW2890337699

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.