ArticleBMC medicine2018
Do hotspots fuel malaria transmission: a village-scale spatio-temporal analysis of a 2-year cohort study in The Gambia.
Article in BMC medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- Pooled it
- Spatial and spatio-temporal analysis for malaria hotspot identification: a scoping review protocol.BMJ open · 2025Article
- Household-level effects of seasonal malaria chemoprevention in the Gambia.Communications medicine · 2024Article
- Asymptomatic Plasmodium falciparum carriage at the end of the dry season is associated with subsequent infection and clinical malaria in Eastern Gambia.Malaria journal · 2024Article
- Article
- The Potential of Surveillance Data for Dengue Risk Mapping: An Evaluation of Different Approaches in Cuba.Tropical medicine and infectious disease · 2023Article
- Spatiotemporal dynamics of malaria in Zanzibar, 2015-2020.BMJ global health · 2023Article
- Evaluation of Dried Blood and Cerebrospinal Fluid Filter Paper Spots for Storing and Transporting Clinical Material for the Molecular Diagnosis of Invasive Meningococcal Disease.International journal of molecular sciences · 2022Article
- Dry season prevalence of Plasmodium falciparum in asymptomatic gambian children, with a comparative evaluation of diagnostic methods.Malaria journal · 2022Article
- 'Bouncing Back' From Subclinical Malaria: Inflammation and Erythrocytosis After Resolution ofFrontiers in immunology · 2022Article
- Fine-scale variation in malaria prevalence across ecological regions in Madagascar: a cross-sectional study.BMC public health · 2021Article
- Spatial-temporal clustering of malaria using routinely collected health facility data on the Kenyan Coast.Malaria journal · 2021Article
- Epidemiological and entomological studies of malaria transmission in Tibati, Adamawa region of Cameroon 6 years following the introduction of long-lasting insecticide nets.Parasites & vectors · 2021Article
- Understanding the spatio-temporal pattern of COVID-19 outbreak in India using GIS and India's response in managing the pandemic.Regional science policy & practice · 2020Article
- Spatial and genetic clustering of Plasmodium falciparum and Plasmodium vivax infections in a low-transmission area of Ethiopia.Scientific reports · 2020Article
- Combination of Serological, Antigen Detection, and DNA Data for Plasmodium falciparum Provides Robust Geospatial Estimates for Malaria Transmission in Haiti.Scientific reports · 2020Article
- Mosquito Exposure and Malaria Morbidity: A Microlevel Analysis of Household Mosquito Populations and Malaria in a Population-Based Longitudinal Cohort in Western Kenya.The Journal of infectious diseases · 2020Article
- Clustering of asymptomatic Plasmodium falciparum infection and the effectiveness of targeted malaria control measures.Malaria journal · 2020Article
- High-resolution micro-epidemiology of parasite spatial and temporal dynamics in a high malaria transmission setting in Kenya.Nature communications · 2019Article
- Socioeconomic and environmental factors associated with malaria hotspots in the Nanoro demographic surveillance area, Burkina Faso.BMC public health · 2019Article
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Authors and funding
11 authors at 6 institutions in 4 countries.
Funding
Abstract
backgroundDespite the biological plausibility of hotspots fueling malaria transmission, the evidence to support this concept has been mixed. If transmission spreads from high burden to low burden households in a consistent manner, then this could have important implications for control and elimination program development.
methodsData from a longitudinal cohort in The Gambia was analyzed. All consenting individuals residing in 12 villages across the country were sampled monthly from June (dry season) to December 2013 (wet season), in April 2014 (mid dry season), and monthly from June to December 2014. A study nurse stationed within each village recorded passively detected malaria episodes between visits. Plasmodium falciparum infections were determined by polymerase chain reaction and analyzed using a geostatistical model.
resultsHousehold-level observed monthly incidence ranged from 0 to 0.50 infection per person (interquartile range = 0.02-0.10) across the sampling months, and high burden households exist across all study villages. There was limited evidence of a spatio-temporal pattern at the monthly timescale irrespective of transmission intensity. Within-household transmission was the most plausible hypothesis examined to explain the observed heterogeneity in infections.
conclusionsWithin-village malaria transmission patterns are concentrated in a small proportion of high burden households, but patterns are stochastic regardless of endemicity. Our findings support the notion of transmission occurring at the household and village scales but not the use of a targeted approach to interrupt spreading of infections from high to low burden areas within villages in this setting.
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