Evidence map›Paper›PMID 30213260›Full record

ArticleWorld journal of surgical oncology2018

Evaluation on prognostic efficacy of lymph nodes ratio (LNR) and log odds of positive lymph nodes (LODDS) in complicated colon cancer: the first study in emergency surgery.

Savino Occhionorelli, Dario Andreotti, Pierpaola Vallese, Lucia Morganti, Domenico Lacavalla, Elena Forini, Giovanni Pascale

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Article in World journal of surgical oncology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Savino OcchionorelliDepartment of Morphology, Surgery and Experimental Medicine, University of Ferrara, via A. Moro, 8, Cona, 44124, Ferrara, Italy.
Dario AndreottiDepartment of Morphology, Surgery and Experimental Medicine, University of Ferrara, via A. Moro, 8, Cona, 44124, Ferrara, Italy.
Pierpaola ValleseDepartment of Oncological and Gastroenterological Surgical Sciences, University of Padova, Padua, Italy.
Lucia MorgantiUnit of General Surgery, State Hospital of San Marino, Borgo Maggiore, Republic of San Marino.
Domenico LacavallaDepartment of Morphology, Surgery and Experimental Medicine, University of Ferrara, via A. Moro, 8, Cona, 44124, Ferrara, Italy.
Elena ForiniUnit of Statistics, S. Anna University Hospital of Ferrara, Ferrara, Italy.
Giovanni PascaleDepartment of Morphology, Surgery and Experimental Medicine, University of Ferrara, via A. Moro, 8, Cona, 44124, Ferrara, Italy. pscgnn@unife.it.ORCID http://orcid.org/0000-0003-0711-5815

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLymph node involvement is one of the most important prognostic factors in colon cancer. Twelve is considered the minimum number of lymph nodes necessary to retain reliable tumour staging, but several factors can potentially influence the lymph node harvesting. Emergent surgery for complicated colon cancer (perforation, occlusion, bleeding) could represent an obstacle to reach the benchmark of 12 nodes with an accurate lymphadenectomy. So, an efficient classification system of lymphatic involvement is crucial to define the prognosis, the indication to adjuvant therapy and the follow-up. This is the first study with the aim to evaluate the efficacy of lymph nodes ratio (LNR) and log odds of positive lymph nodes (LODDS) in the prognostic assessment of patients who undergo to urgent surgery for complicated colonic cancer.

methodsThis is a retrospective study carried out on patients who underwent urgent colonic resection for complicated cancer (occlusion, perforation, bleeding, sepsis). We collected clinical, pathological and follow-up data of 320 patients. Two hundred two patients met the inclusion criteria and were distributed into three groups according to parameter N of TNM, LNR and LODDS. Survival analysis was performed by Kaplan-Meier curves, investigating both overall survival (OS) and disease-free survival (DFS).

resultsThe median number of harvested lymph nodes was 17. In 78.71% (n = 159) of cases, at least 12 lymph nodes were examined. Regarding OS, significant differences from survival curves emerged for ASA score, surgical indication, tumour grading, T parameter, tumour stage, N parameter, LNR and LODDS. In multivariate analysis, only LODDS was found to be an independent prognostic factor. Concerning DFS, we found significant differences between survival curves of sex, surgical indication, T parameter, tumour stage, N parameter, LNR and LODDS, but none of these confirmed its prognostic power in multivariate analysis.

conclusionsWe found that N, LNR and LODDS are all related to 5-year OS and DFS with statistical significance, but only LODDS was found to be an independent prognostic factor for OS in multivariate analysis.

Indexed as

AgedColectomyColonic NeoplasmsEmergenciesFemaleHumansKaplan-Meier EstimateLymphatic MetastasisLymph Node ExcisionLymph NodesMaleNeoplasm Recurrence, LocalNeoplasm StagingPrognosisRetrospective StudiesColon cancerLODDSLymph nodesSurvival analysis

Identifiers

PMID30213260
PMCPMC6137917

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.