Evidence map›Paper›PMID 30213222›Full record

ReviewMolecular imaging

From Micro- to Nano-Multifunctional Theranostic Platform: Effective Ultrasound Imaging Is Not Just a Matter of Scale.

Sara Zullino, Monica Argenziano, Ilaria Stura, Caterina Guiot, Roberta Cavalli

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Molecular imaging. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Sara Zullino1 Department of Neuroscience, University of Turin, Turin, Italy.ORCID 0000-0003-3066-9357
Monica Argenziano2 Department of Drug Science and Technology, University of Turin, Turin, Italy.
Ilaria Stura3 Department of Clinical and Biological Science, University of Turin, Turin, Italy.
Caterina Guiot1 Department of Neuroscience, University of Turin, Turin, Italy.
Roberta Cavalli2 Department of Drug Science and Technology, University of Turin, Turin, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ultrasound Contrast Agents (UCAs) consisting of gas-filled-coated Microbubbles (MBs) with diameters between 1 and 10 µm have been used for a number of decades in diagnostic imaging. In recent years, submicron contrast agents have proven to be a viable alternative to MBs for ultrasound (US)-based applications for their capability to extravasate and accumulate in the tumor tissue via the enhanced permeability and retention effect. After a short overview of the more recent approaches to ultrasound-mediated imaging and therapeutics at the nanoscale, phase-change contrast agents (PCCAs), which can be phase-transitioned into highly echogenic MBs by means of US, are here presented. The phenomenon of acoustic droplet vaporization (ADV) to produce bubbles is widely investigated for both imaging and therapeutic applications to develop promising theranostic platforms.

Indexed as

NanotechnologyTheranostic NanomedicineUltrasonographyAcousticsHumansMicrobubblesVolatilizationacoustic droplet vaporizationdrug deliverynanobubblestherapeutic ultrasoundultrasound contrast agents

Identifiers

PMID30213222
PMCPMC6144578

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.