Evidence map›Paper›PMID 30213195›Full record

ArticleCancer control : journal of the Moffitt Cancer Center

Clinical Significance of Squamous Differentiation in Urothelial Carcinoma of the Bladder.

Akinori Minato, Hirotsugu Noguchi, Ikko Tomisaki, Atsushi Fukuda, Tatsuhiko Kubo, Toshiyuki Nakayama, Naohiro Fujimoto

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer control : journal of the Moffitt Cancer Center. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
4.3field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Akinori Minato1 Department of Urology, University of Occupational and Environmental Health, Kitakyushu, Japan.
Hirotsugu Noguchi2 Department of Public Health, University of Occupational and Environmental Health, Kitakyushu, Japan.
Ikko Tomisaki1 Department of Urology, University of Occupational and Environmental Health, Kitakyushu, Japan.
Atsushi Fukuda1 Department of Urology, University of Occupational and Environmental Health, Kitakyushu, Japan.
Tatsuhiko Kubo2 Department of Public Health, University of Occupational and Environmental Health, Kitakyushu, Japan.
Toshiyuki Nakayama3 Department of Pathology, University of Occupational and Environmental Health, Kitakyushu, Japan.
Naohiro Fujimoto1 Department of Urology, University of Occupational and Environmental Health, Kitakyushu, Japan.
University of Occupational and Environmental Health Japan · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The prognostic value of squamous differentiation (SD) in urothelial carcinoma (UC) of the bladder is unclear. The aim of this study was to identify the clinical significance of SD in UC in terms of oncological outcomes in patients undergoing radical cystectomy (RC). We evaluated consecutive patients with muscle-invasive bladder cancer (MIBC; clinical T2-4aN0M0) treated with RC at our institution from March 2003 to March 2017. We enrolled 20 and 81 patients with UC with SD (UCSD) and pure UC, respectively. Postoperative survival outcomes were compared between the patients with UCSD and pure UC using the Kaplan-Meier method. Pre- and postcystectomy factors that influenced the overall survival (OS) and recurrence-free survival (RFS) were investigated in these patients. Multivariate Cox regression models were used to identify the predictors of OS and RFS. With a median follow-up time of 31 months, the 5-year OS rate of the UCSD and pure UC groups was 41.1% and 69.7% ( P = .002) and the 5-year RFS rate was 51.8% and 59.5% ( P = .027), respectively. The shape of the Kaplan-Meier curves for UCSD suggested a more rapid course of the disease within the first 2 years than observed in pure UC. Multivariate analyses suggested that SD in UC was significantly associated with OS (hazard ratio [HR]: 4.22; 95% confidence interval [CI]: 1.20-14.8; P = .024) and close to significance for a lower RFS (HR: 2.13, 95% CI: 0.74-6.15, P = .064). Our results indicate that SD may be an independent predictor of OS and RFS in UC of MIBC in patients undergoing RC.

Indexed as

Cell DifferentiationAgedCarcinoma, Squamous CellCarcinoma, Transitional CellCystectomyDisease-Free SurvivalEpithelial CellsFemaleFollow-Up StudiesHumansKaplan-Meier EstimateMaleMiddle AgedPrognosisRetrospective StudiesSurvival Rateprognosisradical cystectomysquamous differentiationurothelial carcinomavariant histology

Identifiers

PMID30213195
PMCPMC6144505
OpenAlexW2890190580

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.