ArticleNutrients2018
Omega-3 Fatty Acids Prevent Early Pancreatic Carcinogenesis via Repression of the AKT Pathway.
Open access · goldAbstract read
In one paragraph
Article in Nutrients, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 21% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.
- Mechanisms of obesity- and diabetes mellitus-related pancreatic carcinogenesis: a comprehensive and systematic review.Signal transduction and targeted therapy · 2023Pooled it
- Metabolic plasticity in pancreatic ductal adenocarcinoma progression and response to treatment.Molecular cancer · 2026Review
- The ratio of omega-6 fatty acids to omega-3 fatty acids mediating the effect of gastroesophageal reflux disease on pancreatic cancer risk: a two-step mediation Mendelian randomisation study.BMC gastroenterology · 2025Article
- Novel inhibitory effect of Omega-3 fatty acids regulating pancreatic cancer progression.Carcinogenesis · 2025Article
- Associations of specific food sources of dietary fat with prostate cancer incidence and mortality: results from a large prospective cohort.Frontiers in nutrition · 2025Article
- Cell Membrane Fatty Acids and PIPs Modulate the Etiology of Pancreatic Cancer by Regulating AKT.Nutrients · 2024Article
- Oncometabolites in pancreatic cancer: Strategies and its implications.World journal of experimental medicine · 2024Review
- Raman Imaging-A Valuable Tool for Tracking Fatty Acid Metabolism-Normal and Cancer Human Colon Single-Cell Study.International journal of molecular sciences · 2024Article
- NGF-mediated crosstalk: unraveling the influence of metabolic deregulation on the interplay between neural and pancreatic cancer cells and its impact on patient outcomes.Frontiers in pharmacology · 2024Review
- Palmitoylation-driven PHF2 ubiquitination remodels lipid metabolism through the SREBP1c axis in hepatocellular carcinoma.Nature communications · 2023Article
- Possible molecular exploration of herbal pair Haizao-Kunbu in the treatment of Graves' disease by network pharmacology, molecular docking, and molecular dynamic analysis.Frontiers in endocrinology · 2023Article
- Body mass index, C-reactive protein, and pancreatic cancer: A Mendelian randomization analysis to investigate causal pathways.Frontiers in oncology · 2023Article
- Modifiable and Non-Modifiable Risk Factors for the Development of Non-Hereditary Pancreatic Cancer.Medicina (Kaunas, Lithuania) · 2022Review
- Obesity and Pancreatic Cancer: Recent Progress in Epidemiology, Mechanisms and Bariatric Surgery.Biomedicines · 2022Review
- NSAIDs and Cancer Resolution: New Paradigms beyond Cyclooxygenase.International journal of molecular sciences · 2022Review
- The role of metabolic reprogramming in pancreatic cancer chemoresistance.Frontiers in pharmacology · 2022Review
- Mitophagy-mediated molecular subtypes depict the hallmarks of the tumour metabolism and guide precision chemotherapy in pancreatic adenocarcinoma.Frontiers in cell and developmental biology · 2022Article
- How cancer cells remodel lipid metabolism: strategies targeting transcription factors.Lipids in health and disease · 2021Review
- The molecular biology of pancreatic adenocarcinoma: translational challenges and clinical perspectives.Signal transduction and targeted therapy · 2021Review
- Eicosapentaenoic Acid InhibitsBiomolecules · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
18 authors at 3 institutions in 2 countries.
Yongzeng DingDepartment of Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA. ding.zheng@northwestern.edu.
Bhargava MullapudiDepartment of Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA. mullapudi.bhargav@gmail.com.
Carolina TorresDivision of Gastroenterology, Department of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA. ctorres@uic.edu.ORCID 0000-0002-7908-6884
Emman MascariñasDepartment of Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA. wemascarinas@gmail.com.
Georgina MancinelliDivision of Gastroenterology, Department of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA. gms891@gmail.com.
Andrew M DiazDivision of Gastroenterology, Department of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA. amdiaz@atsu.edu.
Ronald McKinneyDivision of Gastroenterology, Department of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA. mckinney@uic.edu.
Morgan BarronDepartment of Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA. mrbarron01@gmail.com.
Michelle SchultzDepartment of Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA. buffalosoldierms@gmail.com.
Michael HeifermanDepartment of Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA. mikeheif@gmail.com.
Mireille WojtanekDepartment of Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA. mireillewojtanek@gmail.com.
Kevin AdrianDepartment of Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA. KevinAdrian@bridgewatermcg.com.
Brian DeCantDepartment of Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA. bdecant0823@gmail.com.
Sambasiva RaoDivision of Gastroenterology, Department of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA. s-rao@northwestern.edu.
Michel OuelletteDepartment of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA. mouellet@unmc.edu.
Ming-Sound TsaoToronto General Hospital, 200 Elizabeth St., Toronto, ON M5G 2C4, Canada. ming.tsao@uhn.ca.
David J BentremDepartment of Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA. dbentrem@northwestern.edu.
Paul J GrippoDepartment of Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA. pgrippo@uic.edu.ORCID 0000-0002-6374-1282
Northwestern University · USUniversity of Illinois Chicago · USToronto General Hospital · CA
Funding
Non Invasive Treatment Response Monitoring and molecular characterization of NSCLC using Cell-free DNA isolated by an AC Electrokinetic DeviceR01CA161283 · NCI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI GRIPPO, PAUL J · 2012 to 2016
$1.8MNational Institutes of Health NIH 1R01CA16128301A1NCI NIH HHS R01 CA161283University of Illinois Departmental Funds to PG
Abstract
Pancreatic cancer remains a daunting foe despite a vast number of accumulating molecular analyses regarding the mutation and expression status of a variety of genes. Indeed, most pancreatic cancer cases uniformly present with a mutation in the
Indexed as
DietSignal TransductionAnimalsAnticarcinogenic AgentsApoptosisCell LineCell ProliferationCell SurvivalCell Transformation, NeoplasticDown-RegulationFatty Acids, Omega-3HumansMice, TransgenicMutationNeoplasms, ExperimentalPancreatic DuctsAnticarcinogenic AgentsFatty Acids, Omega-3Hras protein, mouseKRAS protein, humanProto-Oncogene Proteins c-aktProto-Oncogene Proteins p21(ras)chemopreventionneoplastic diseasepancreatic cancerpolyunsaturated fatty acidsproliferation
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.