Evidence map›Paper›PMID 30213076›Full record

ArticleMarine drugs2018

Stress-Driven Discovery of New Angucycline-Type Antibiotics from a Marine

Najeeb Akhter, Yaqin Liu, Bibi Nazia Auckloo, Yutong Shi, Kuiwu Wang, Juanjuan Chen, Xiaodan Wu, Bin Wu

Abstract readEvaluation Study
In one paragraph

Article in Marine drugs, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Najeeb AkhterOcean College, Zhejiang University, Hangzhou 310058, China. na_memon@yahoo.com.
Yaqin LiuDepartment of Chemistry, Zhejiang University, Hangzhou 301000, China. yaqin86@zju.edu.cn.
Bibi Nazia AucklooOcean College, Zhejiang University, Hangzhou 310058, China. naz22ia@hotmail.com.
Yutong ShiOcean College, Zhejiang University, Hangzhou 310058, China. 11434028@zju.edu.cn.
Kuiwu WangDepartment of Chemistry, Zhejiang Gongshang University, Hangzhou 310012, China. wkwnpc@zjgsu.edu.cn.
Juanjuan ChenKey Laboratory of Applied Marine Biotechnology, Ningbo University, Chinese Ministry of Education, Ningbo 315211, China. chenjuanjuan@nbu.edu.cn.
Xiaodan WuCentre of Analysis and Measurement, Zhejiang University, Hangzhou 310058, China. wxd_zju@163.com.
Bin WuOcean College, Zhejiang University, Hangzhou 310058, China. wubin@zju.edu.cn.

Funding

National Natural Science Foundation of China 81573306
6 · The paper itself

Abstract

Natural products from marine actinomycetes remain an important resource for drug discovery, many of which are produced by the genus, Streptomyces. However, in standard laboratory conditions, specific gene clusters in microbes have long been considered silent or covert. Thus, various stress techniques activated latent gene clusters leading to isolation of potential metabolites. This study focused on the analysis of two new angucycline antibiotics isolated from the culture filtrate of a marine

Indexed as

Anti-Bacterial AgentsAquatic OrganismsBacteriaBiological FactorsBiosynthetic PathwaysDrug DiscoveryMass SpectrometryMetals, HeavyMicrobial Sensitivity TestsMultigene FamilyStreptomycesStress, PhysiologicalAnti-Bacterial AgentsBiological FactorsMetals, Heavyantimicrobial activitymarine microorganismsmetal stress techniquepolyketide antibioticsStreptomyces pratensis

Identifiers

PMID30213076
PMCPMC6163593

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.