ReviewPharmaceutics2018
Developments in Taste-Masking Techniques for Traditional Chinese Medicines.
Review in Pharmaceutics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed.
- Optimization of Xiaoer Lingyin granule formulation using single-factor and response surface methodology.RSC advances · 2026Article
- Bitter Compounds in Medicinal Food Plants Based on Traditional Chinese Medicine: Analysis and Regulation Strategies from Chemical Structure to Perception Mechanisms.Molecules (Basel, Switzerland) · 2026Review
- Formulation Design of a Hot-melt Extrusion-Based Amorphous Solid Dispersion to Optimize Palatability of Berberine Hydrochloride with In Vitro and In Vivo Evaluation.AAPS PharmSciTech · 2026Article
- Development and in vitro/in vivo evaluation of taste-masked orodispersible films of dapoxetine hydrochloride using ion exchange resins.Drug delivery and translational research · 2025Article
- Taste Masking of Primaquine Phosphate: A Comparative Evaluation of Three Taste Masking Agents.AAPS PharmSciTech · 2025Article
- Preparation and Characterization of Diclofenac Sodium-Purolite A430MR Complexes for Taste Masking.AAPS PharmSciTech · 2025Article
- Recent Progress in Nano-TCM Active Ingredient Co-Delivery Systems for Inflammation-Mediated Diseases.International journal of nanomedicine · 2025Review
- Research progress of dissolving microneedles in the field of component administration of traditional Chinese medicine.Frontiers in pharmacology · 2025Review
- Biochemical Composition, Antioxidant Capacity and Protective Effects of Three Fermented Plants Beverages on Hepatotoxicity and Nephrotoxicity Induced by Carbon Tetrachloride in Mice.Indian journal of microbiology · 2024Article
- One of the major challenges of masking the bitter taste in medications: an overview of quantitative methods for bitterness.Frontiers in chemistry · 2024Review
- Efficacy of botanical lozenges in the treatment of chronic pharyngitis: a randomized controlled trial.Frontiers in pharmacology · 2024Article
- Strategies for oral delivery of bioactive peptides with focus on debittering and masking.NPJ science of food · 2023Review
- Antioxidant capacity, flavor and physicochemical properties of FH06 functional beverage fermented by lactic acid bacteria: a promising method to improve antioxidant activity and flavor of plant functional beverage.Applied biological chemistry · 2023Article
- New strategies for identifying and masking the bitter taste in traditional herbal medicines: The example of Huanglian Jiedu Decoction.Frontiers in pharmacology · 2022Article
- Nanoformulation of Plant-Based Natural Products for Type 2 Diabetes Mellitus: From Formulation Design to Therapeutic Applications.Current therapeutic research, clinical and experimental · 2022Review
- Physicochemical, Digestive, and Sensory Properties of Panax Notoginseng Saponins Encapsulated by Polymerized Whey Protein.Foods (Basel, Switzerland) · 2021Article
- Pharmacokinetics of five phthalides in volatile oil of Ligusticum sinense Oliv.cv. Chaxiong, and comparison study on physicochemistry and pharmacokinetics after being formulated into solid dispersion and inclusion compound.BMC complementary medicine and therapies · 2021Article
- Technological evolution of cyclodextrins in the pharmaceutical field.Journal of drug delivery science and technology · 2021Review
- Spray Drying for the Encapsulation of Oils-A Review.Molecules (Basel, Switzerland) · 2020Review
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A variety of pharmacologically active substances, including chemotherapeutic drugs and the substances from traditional Chinese medicine (TCM), always exhibit potent bioactivities after oral administration. However, their unpleasant taste (such as bitterness) and/or odor always decrease patient compliance and thus compromise their curative efficacies in clinical application. Therefore, the developments of taste-masking techniques are of great significance in improving their organoleptic properties. However, though a variety of taste-masking techniques have been successfully used to mask the unpalatable taste of chemotherapeutic drugs, their suitability for TCM substances is relatively limited. This is mainly due to the fact that the bitter ingredients existing in multicomponent TCM systems (i.e., effective fractions, single Chinese herbs, and compound preparations) are always unclear, and thus, there is lack of tailor-made taste-masking techniques to be utilized to conceal their unpleasant taste. The relevant studies are also relatively limited. As a whole, three types of taste-masking techniques are generally applied to TCM, including (i) functional masking via sweeteners, bitter blockers, and taste modifiers; (ii) physical masking via polymer film-coating or lipid barrier systems; and (iii) biochemical masking via intermolecular interaction, β-cyclodextrin inclusion, or ion-exchange resins. This review fully summarizes the results reported in this field with the purpose of providing an informative reference for relevant readers.
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