Observational studyAnnals of behavioral medicine : a publication of the Society of Behavioral Medicine2018
Adverse Childhood Experiences and Symptoms of Urologic Chronic Pelvic Pain Syndrome: A Multidisciplinary Approach to the Study of Chronic Pelvic Pain Research Network Study.
Observational study in Annals of behavioral medicine : a publication of the Society of Behavioral Medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01098279 (Multidisciplinary Approach to the Study of Chronic Pelvic Pain), which is not on this map. Cited by 22 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Multidisciplinary Approach to the Study of Chronic Pelvic Pain: Trans-MAPP Epidemiology and Phenotyping (EP) Study
Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 73 citations in OpenAlex.
- Adverse childhood experience is associated with an increased risk of reporting chronic pain in adulthood: a stystematic review and meta-analysis.European journal of psychotraumatology · 2023Pooled it
- The role of catastrophizing in chronic cyclical pelvic pain: A systematic review and meta-analysis.Women's health (London, England)Pooled it
- Review
- Low-intensity energy shock wave therapy modulates bladder function and anxiety-like behavior in maternal separation rats.International urology and nephrology · 2026Article
- A study design for modulating two components of the risk architecture of chronic pain: adverse life events and pain catastrophising.Frontiers in psychology · 2026Article
- Association between adverse childhood experiences and health related quality of life in adult cancer survivors in the United States.Journal of cancer survivorship : research and practice · 2025Article
- Latent bladder hypersensitivity induced by neonatal cystitis in rats unmasked by segmental but not hetero-segmental inflammation.Neuroscience letters · 2025Article
- Deciphering nociplastic pain: clinical features, risk factors and potential mechanisms.Nature reviews. Neurology · 2024Review
- Cognitive Behavioral Therapy for Chronic Pelvic Pain: What Is It and Does It Work?The Journal of urology · 2024Review
- Interstitial cystitis-an imbalance of risk and protective factors?Frontiers in pain research (Lausanne, Switzerland) · 2024Review
- Early and recent exposure to adversity, TLR-4 stimulated inflammation, and diurnal cortisol in women with interstitial cystitis/bladder pain syndrome: A MAPP research network study.Brain, behavior, and immunity · 2023Article
- What is the association between childhood adversity and subsequent chronic pain in adulthood? A systematic review.BJA open · 2023Review
- Interpersonal violence and painful bladder symptoms in community-dwelling midlife to older women.American journal of obstetrics and gynecology · 2022Article
- Multi-Site Observational Study to Assess Biomarkers for Susceptibility or Resilience to Chronic Pain: The Acute to Chronic Pain Signatures (A2CPS) Study Protocol.Frontiers in medicine · 2022Article
- Reduced Hippocampal Volume and Neurochemical Response to Adult Stress Exposure in a Female Mouse Model of Urogenital Hypersensitivity.Frontiers in pain research (Lausanne, Switzerland) · 2022Article
- The impact of foot shock-induced stress on pain-related behavior associated with burn injury.Burns : journal of the International Society for Burn Injuries · 2021Article
- Characterizing Pain and Generalized Sensory Sensitivity According to Trauma History Among Patients With Knee Osteoarthritis.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2021Article
- Adverse childhood experience and adult persistent pain and disability: protocol for a systematic review and meta-analysis.Systematic reviews · 2020Article
- The association between exposure to childhood maltreatment and the subsequent development of functional somatic and visceral pain syndromes.EClinicalMedicine · 2020Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 6 institutions in 1 country.
Funding
Abstract
Background: Adverse Childhood Experiences (ACEs) such as sexual and physical violence, serious illness, and bereavement have been linked to number of chronic pain conditions in adulthood, and specifically to urologic chronic pelvic pain syndrome (UCPPS). Purpose: We sought to characterize the prevalence of ACEs in UCPPS using a large well-characterized cohort in comparison with a group of healthy controls. We also sought to determine the association of ACE severity with psychological factors known to impact pain and to determine whether ACEs are associated with patterns of improvement or worsening of symptom over a year of naturalistic observation. Methods: For longitudinal analyses we used functional clusters identifying broad classes of (a) improved, (b) worsened, and (c) stable groups for genitourinary pain and urinary symptoms. We employed a mediation/path analysis framework to determine whether ACEs influenced 1 year outcomes directly, or indirectly through worse perceptions of physical well-being. Results: ACE severity was elevated in UCPPS (n = 421) participants compared with healthy controls (n = 414; p < .001), and was most strongly associated with factors associated with complex chronic pain, including more diffuse pain, comorbid functional symptoms/syndromes, and worse perceived physical well-being (all p < .001). Finally, worse physical well-being mediated the relationship between ACE severity and less likelihood of painful symptom improvement (OR = .871, p = .007)) and a greater likelihood of painful symptom worsening (OR = 1.249, p = .003) at 1 year. Conclusions: These results confirm the association between ACEs and UCPPS symptoms, and suggest potential targets for therapeutic interventions in UCPPS. Clinical Trial registration: NCT01098279.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.