ArticleClinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology2018
Effect of epileptiform abnormality burden on neurologic outcome and antiepileptic drug management after subarachnoid hemorrhage.
Article in Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 2 of them syntheses that pooled it.
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Who cites it
28 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Worldwide research trends of post-subarachnoid hemorrhage epilepsy from 1995 to 2024: a bibliometric analysis.Frontiers in neurology · 2025Pooled it
- Duration and choices of prophylactic anticonvulsants in subarachnoid hemorrhage: a systematic review and meta-analysis.Neurosurgical review · 2021Pooled it
- Harnessing Scalp Gamma Oscillations to Predict Clinical Outcomes in Patients with Periodic Discharges.Neurocritical care · 2026Article
- Intracranial electroencephalographic approaches in the intensive care unit: Safety, feasibility, and coverage.Epilepsia · 2026Article
- Antiseizure Medication Use and Outcomes After Suspected or Confirmed Acute Symptomatic Seizures.JAMA neurology · 2024Article
- How many patients do you need? Investigating trial designs for anti-seizure treatment in acute brain injury patients.Annals of clinical and translational neurology · 2024Article
- Effects of epileptiform activity on discharge outcome in critically ill patients in the USA: a retrospective cross-sectional study.The Lancet. Digital health · 2023Article
- Interrater Reliability of Expert Electroencephalographers Identifying Seizures and Rhythmic and Periodic Patterns in EEGs.Neurology · 2023Article
- Development of Expert-Level Classification of Seizures and Rhythmic and Periodic Patterns During EEG Interpretation.Neurology · 2023Article
- Comparative Effectiveness and Safety of Seizure Prophylaxis Among Adults After Acute Ischemic Stroke.Stroke · 2023Article
- Epileptiform activity in the acute phase of stroke predicts the outcomes in patients without seizures.Frontiers in neurology · 2023Article
- Electrographic Seizures in the Critically Ill.Neurologic clinics · 2022Review
- Spontaneous subarachnoid haemorrhage.Lancet (London, England) · 2022Review
- Antiseizure Medication Treatment and Outcomes in Patients with Subarachnoid Hemorrhage Undergoing Continuous EEG Monitoring.Neurocritical care · 2022Observational
- Neuroelectric Mechanisms of Delayed Cerebral Ischemia after Aneurysmal Subarachnoid Hemorrhage.International journal of molecular sciences · 2022Review
- Using electronic health data to explore effectiveness of ICU EEG and anti-seizure treatment.Annals of clinical and translational neurology · 2021Article
- Electroencephalography, Hospital Complications, and Longitudinal Outcomes After Subarachnoid Hemorrhage.Neurocritical care · 2021Article
- Association of Epileptiform Abnormality on Electroencephalography with Development of Epilepsy After Acute Brain Injury.Neurocritical care · 2021Article
- Long-term continuation of anti-seizure medications after acute stroke.Annals of clinical and translational neurology · 2021Article
- Automated Annotation of Epileptiform Burden and Its Association with Outcomes.Annals of neurology · 2021Article
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Authors and funding
12 authors.
Funding
Abstract
objectiveTo quantify the burden of epileptiform abnormalities (EAs) including seizures, periodic and rhythmic activity, and sporadic discharges in patients with aneurysmal subarachnoid hemorrhage (aSAH), and assess the effect of EA burden and treatment on outcomes.
methodsRetrospective analysis of 136 high-grade aSAH patients. EAs were defined using the American Clinical Neurophysiology Society nomenclature. Burden was defined as prevalence of <1%, 1-9%, 10-49%, 50-89%, and >90% for each 18-24 hour epoch. Our outcome measure was 3-month Glasgow Outcome Score.
results47.8% patients had EAs. After adjusting for clinical covariates EA burden on first day of recording and maximum daily burden were associated with worse outcomes. Patients with higher EA burden were more likely to be treated with anti-epileptic drugs (AEDs) beyond the standard prophylactic protocol. There was no difference in outcomes between patients continued on AEDs beyond standard prophylaxis compared to those who were not.
conclusionsHigher burden of EAs in aSAH independently predicts worse outcome. Although nearly half of these patients received treatment, our data suggest current AED management practices may not influence outcome. SIGNIFICANCE: EA burden predicts worse outcomes and may serve as a target for prospective interventional controlled studies to directly assess the impact of AEDs, and create evidence-based treatment protocols.
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