Evidence map›Paper›PMID 30212746›Full record

ArticleBrain and language2018

Cortical regions supporting reading comprehension skill for single words and discourse.

K Ryherd, K Jasinska, J A Van Dyke, Y-H Hung, E Baron, W E Mencl, J Zevin, N Landi

Abstract read
In one paragraph

Article in Brain and language, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Structural Brain Correlates of Poor Reading Comprehension.Neurobiology of language (Cambridge, Mass.) · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

K RyherdDepartment of Psychological Sciences, University of Connecticut, Storrs, CT, United States; Haskins Laboratories, New Haven, CT, United States; CT Institute for the Brain and Cognitive Sciences, Storrs, CT, United States.
K JasinskaDepartment of Linguistics and Cognitive Science, University of Delaware, United States; Haskins Laboratories, New Haven, CT, United States.
J A Van DykeHaskins Laboratories, New Haven, CT, United States; CT Institute for the Brain and Cognitive Sciences, Storrs, CT, United States.
Y-H HungHaskins Laboratories, New Haven, CT, United States.
E BaronHaskins Laboratories, New Haven, CT, United States.
W E MenclHaskins Laboratories, New Haven, CT, United States; Department of Linguistics, Yale University, New Haven, CT, United States.
J ZevinHaskins Laboratories, New Haven, CT, United States; Departments of Psychology and Linguistics, University of Southern California, Los Angeles, CA, United States.
N LandiDepartment of Psychological Sciences, University of Connecticut, Storrs, CT, United States; Haskins Laboratories, New Haven, CT, United States; Yale Child Study Center, Yale University, New Haven, CT, United States; CT Institute for the Brain and Cognitive Sciences, Storrs, CT, United States. Electronic address: nicole.landi@uconn.edu.

Funding

Visual word identification: phonology &morphologyP01HD001994 · NICHD · HASKINS LABORATORIES, INC. · PI MENCL, EINAR · 1985 to 2016
$23.5M
Experiential and child factors that determine acquisition of orthographic-phonological regularities in a quasi-regular writing system: An integrated behavioral/computational/neurobiological approachP20HD091013 · NICHD · FLORIDA STATE UNIVERSITY · PI COMPTON, DONALD L · 2017 to 2025
$4.2M
Retrieval interference in skilled and unskilled reading comprehsensionR01HD073288 · NICHD · HASKINS LABORATORIES, INC. · PI VAN DYKE, JULIE A · 2013 to 2017
$3.6M
Neurochemistry as a moderator of brain networks for readingR01HD086168 · NICHD · HASKINS LABORATORIES, INC. · PI HOEFT, FUMIKO, PUGH, KENNETH R. · 2016 to 2020
$3.2M
Neurobiology of language function in adolescents exposed to cocaine in uteroR21DA030665 · NIDA · YALE UNIVERSITY · PI MAYES, LINDA CAROL · 2011 to 2012
$410k
Neurocognitive development in RD children with/without general cognitive deficitsR03HD053409 · NICHD · HASKINS LABORATORIES, INC. · PI LANDI, NICOLE · 2008 to 2009
$141k
NICHD NIH HHS L30 HD054250NICHD NIH HHS P01 HD001994NICHD NIH HHS P20 HD091013NICHD NIH HHS R01 HD073288NICHD NIH HHS R01 HD086168NICHD NIH HHS R03 HD053409NIDA NIH HHS R21 DA030665
6 · The paper itself

Abstract

A substantial amount of variation in reading comprehension skill is explained by listening comprehension skill, suggesting tight links between printed and spoken discourse processing. In addition, both word level (e.g., vocabulary) and discourse-level sub-skills (e.g., inference-making) support overall comprehension. However, while these contributions to variation in comprehension skill have been well-studied behaviorally, the underlying neurobiological basis of these relationships is less well understood. In order to examine the neural bases of individual differences in reading comprehension as a function of input modality and processing level, we examined functional neural activation to both spoken and printed single words and passages in adolescents with a range of comprehension skill. Data driven Partial Least Squares Correlation (PLSC) analyses revealed that comprehension skill was positively related to activation in a number of regions associated with discourse comprehension and negatively related to activation in regions associated with executive function and memory across processing levels and input modalities.

Indexed as

ComprehensionReadingAdolescentCerebral CortexExecutive FunctionFemaleHumansMaleVocabularyfMRIModalityNaturalistic designPartial Least Squares Correlation (PLSC)Processing levelReading comprehension

Identifiers

PMID30212746
PMCPMC6447036

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.