Evidence map›Paper›PMID 30212737›Full record

ReviewCurrent opinion in plant biology2018

Sizing up the cell cycle: systems and quantitative approaches in Chlamydomonas.

James G Umen

Abstract readReview
In one paragraph

Review in Current opinion in plant biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. The Papain-like Cysteine ProteaseInternational journal of molecular sciences · 2021
    Article
  9. Article
  10. The biosynthesis of phospholipids is linked to the cell cycle in a model eukaryote.Biochimica et biophysica acta. Molecular and cell biology of lipids · 2021
    Article
  11. Article
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

James G UmenDonald Danforth Plant Science Center, 975 N. Warson Rd., St. Louis, MO 63132, USA. Electronic address: jumen@danforthcenter.org.

Funding

Stochastic hybrid systems approach to uncovering cell-size control mechanisms R01GM126557 · NIGMS · UNIVERSITY OF DELAWARE · PI SINGH, ABHYUDAI · 2017 to 2019
$675k
NIGMS NIH HHS R01 GM126557
6 · The paper itself

Abstract

The unicellular green alga Chlamydomonas provides a simplified model for defining core cell cycle functions conserved in the green lineage and for understanding multiple fission, a common cell cycle variation found in many algae. Systems-level approaches including a recent groundbreaking screen for conditional lethal cell cycle mutants and genome-wide transcriptome analyses are revealing the complex relationships among cell cycle regulators and helping define roles for CDKA/CDK1 and CDKB, the latter of which is unique to the green lineage and plays a central role in mitotic regulation. Genetic screens and quantitative single-cell analyses have provided insight into cell-size control during multiple fission including the identification of a candidate `sizer' protein. Quantitative single-cell tracking and modeling are promising approaches for gaining additional insight into regulation of cellular and subcellular scaling during the Chlamydomonas cell cycle.

Indexed as

Cell CycleCell SizeChlamydomonas reinhardtiiCircadian RhythmGene Expression ProfilingGene Expression Regulation, PlantMutationPlant ProteinsSingle-Cell AnalysisStochastic ProcessesSystems BiologyPlant Proteins

Identifiers

PMID30212737
PMCPMC6269190

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.