ArticleCell host & microbe2018
The Inhibitory Innate Immune Sensor NLRP12 Maintains a Threshold against Obesity by Regulating Gut Microbiota Homeostasis.
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Article in Cell host & microbe, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 122 papers, 2 of them syntheses that pooled it.
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122citing papers in PubMed, 2 pooled it
7.9field-weighted citation impact, top 2% of its field
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Who cites it
122 citing papers in PubMed, 2 syntheses or guidelines pooled it, 222 citations in OpenAlex.
- Gut Microbiota Characteristics of People with Obesity by Meta-Analysis of Existing Datasets.Nutrients · 2022Pooled it
- Obesity-related gut hormones and cancer: novel insight into the pathophysiology.International journal of obesity (2005) · 2021Pooled it
- Gut microbiota predicts body fat change following a low-energy diet: a PREVIEW intervention study.Genome medicine · 2022Trial
- Effectiveness of Multistrain Probiotic Formulation on Common Infectious Disease Symptoms and Gut Microbiota Modulation in Flu-Vaccinated Healthy Elderly Subjects.BioMed research international · 2022Trial
- Lachnospiraceae in the Food-Gut Axis: A Critical Review of Dietary Modulation, Immune Regulation, and Translational Barriers.Comprehensive reviews in food science and food safety · 2026Review
- Defined human Clostridia consortia reverse colitis via dual effects of tryptophan metabolites on microbiota and immunity.Cell host & microbe · 2026Article
- Gut microbiota composition outperforms chronological age in predicting systemic inflammation and incident disease risk.Nature communications · 2026Article
- Intestinal fructose catabolism promotes obesity and insulin resistance via ileal lacteal remodeling.Science advances · 2026Article
- Dismissing-then-recruiting: a unique mechanism for symbiont recruitment and lignocellulose degradation in gut of black soldier fly larvae.Microbiome · 2026Article
- Postbiotics: emerging regulatory mechanisms and therapeutic applications in obesity and its complications.International journal of obesity (2005) · 2026Review
- Decoding the gut microbiota-mitochondrial-inflammasome axis in cardiovascular disease.Molecular and cellular biochemistry · 2026Review
- NLRP12 Deficiency Enhances Tofacitinib Efficacy in DSS Colitis Via STAT1-M1 Polarization.Inflammation · 2026Article
- NLR inflammasome pathways: key targets for pathogenesis and therapy of metabolic diseases.Frontiers in immunology · 2026Review
- Perinatal antibiotics in a db/db mouse model impact obesity and hyperglycemia in a microbiome-dependent manner.Frontiers in microbiomes · 2026Article
- Article
- Moderate altitude exposure induced gut microbiota enterotype shifts impacting host serum metabolome and phenome.BMC microbiology · 2025Article
- Genetic and molecular landscape of comorbidities in people living with HIV.Nature medicine · 2025Article
- NFAT5 dictates crosstalk between intestinal epithelial regenerative capacity and microbiota in murine colitis models.The Journal of clinical investigation · 2025Article
- Curcumin Ameliorates DSS-Induced Colitis in Mice Through Modulation of Gut Microbiota and Metabolites.Life (Basel, Switzerland) · 2025Article
- Article
62 more citing papers are in PubMed but not listed here.
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Authors and funding
20 authors at 5 institutions in 2 countries.
Agnieszka D TruaxLineberger Comprehensive Cancer Center, UNC-Chapel Hill, Chapel Hill, NC, USA; Department of Genetics, UNC-Chapel Hill, Chapel Hill, NC, USA.
Liang ChenDepartment of Genetics, UNC-Chapel Hill, Chapel Hill, NC, USA; Department of Microbiology and Immunology, UNC-Chapel Hill, Chapel Hill, NC, USA.
Jason W TamLineberger Comprehensive Cancer Center, UNC-Chapel Hill, Chapel Hill, NC, USA.
Ning ChengLineberger Comprehensive Cancer Center, UNC-Chapel Hill, Chapel Hill, NC, USA; Oral and Craniofacial Biomedicine Program, UNC-Chapel Hill, Chapel Hill, NC, USA.
Hao GuoLineberger Comprehensive Cancer Center, UNC-Chapel Hill, Chapel Hill, NC, USA.
A Alicia KoblanskyLineberger Comprehensive Cancer Center, UNC-Chapel Hill, Chapel Hill, NC, USA; Department of Genetics, UNC-Chapel Hill, Chapel Hill, NC, USA.
Wei-Chun ChouLineberger Comprehensive Cancer Center, UNC-Chapel Hill, Chapel Hill, NC, USA; Department of Genetics, UNC-Chapel Hill, Chapel Hill, NC, USA.
Justin E WilsonLineberger Comprehensive Cancer Center, UNC-Chapel Hill, Chapel Hill, NC, USA; Department of Genetics, UNC-Chapel Hill, Chapel Hill, NC, USA.
W June BrickeyLineberger Comprehensive Cancer Center, UNC-Chapel Hill, Chapel Hill, NC, USA; Department of Microbiology and Immunology, UNC-Chapel Hill, Chapel Hill, NC, USA.
Alex PetrucelliLineberger Comprehensive Cancer Center, UNC-Chapel Hill, Chapel Hill, NC, USA; Department of Genetics, UNC-Chapel Hill, Chapel Hill, NC, USA.
Rongrong LiuLineberger Comprehensive Cancer Center, UNC-Chapel Hill, Chapel Hill, NC, USA.
Daniel E CooperDepartment of Nutrition, Gillings School of Global Public Health, UNC-Chapel Hill, Chapel Hill, NC, USA.
Mark J KoenigsknechtDepartment of Internal Medicine, Division of Infectious Diseases, University of Michigan, Ann Arbor, MI, USA.
Vincent B YoungDepartment of Internal Medicine, Division of Infectious Diseases, University of Michigan, Ann Arbor, MI, USA.
Mihai G NeteaDepartment of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, the Netherlands.
Rinke StienstraDepartment of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, the Netherlands.
R Balfour SartorCenter for Gastrointestinal Biology and Disease, Departments of Medicine, Microbiology, and Immunology, UNC-Chapel Hill, Chapel Hill, NC, USA.
Stephanie A MontgomeryLineberger Comprehensive Cancer Center, UNC-Chapel Hill, Chapel Hill, NC, USA; Department of Pathology and Laboratory Medicine, UNC-Chapel Hill, Chapel Hill, NC, USA.
Rosalind A ColemanDepartment of Nutrition, Gillings School of Global Public Health, UNC-Chapel Hill, Chapel Hill, NC, USA.
Jenny P-Y TingLineberger Comprehensive Cancer Center, UNC-Chapel Hill, Chapel Hill, NC, USA; Department of Genetics, UNC-Chapel Hill, Chapel Hill, NC, USA; Department of Microbiology and Immunology, UNC-Chapel Hill, Chapel Hill, NC, USA. Electronic address: jenny_ting@med.unc.edu.
University of North Carolina at Chapel Hill · USUniversity of North Carolina Health Care · USUNC Lineberger Comprehensive Cancer CenterRadboud University Nijmegen · NLUniversity of Michigan–Ann Arbor · US
Funding
Virology Research Program (Program 4)P30CA016086 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Deborah F. Tate · 1985 to 2026
$201.5MUNIV OF NORTH CAROLINA CLINICAL NUTRITION RESEARCH UNITP30DK056350 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SUSAN M. SMITH · 1999 to 2026
$31.6MPILOT AND FEASIBILITY STUDIESP30DK034987 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ROBERT S. SANDLER · 1985 to 2026
$30.5MIntegrated Training in Cancer Model SystemsT32CA009156 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DER, CHANNING J. · 1985 to 2020
$19.7MRole of IL-10 in APC Regulation of Protective vs. Pathogenic T Cell Responses toP01DK094779 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SHEIKH, SHEHZAD Z. · 2013 to 2023
$17.9MNational Gnotobiotic Rodent Resource CenterP40OD010995 · OD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Ryan B Sartor · 2012 to 2026
$9.7MGASTROENTEROLOGY RESEARCH TRAININGT32DK007737 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SHEHZAD Z. SHEIKH · 1996 to 2026
$7.8MMolecular and Functional Analysis of NLR Family MembersR01AI029564 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Jenny P Ting · 1991 to 2026
$6.0MPlexin-A1: Regulation by CIITA and Immunologic FunctionR37AI029564 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI TING, JENNY P · 2008 to 2017
$3.8MColitis, Colon Cancer and the NLR FamilyR01CA156330 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI TING, JENNY P · 2011 to 2019
$3.0MPlexin-A1: Regulation by CIITA and immunologic functionR56AI029564 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI TING, JENNY P.Y. · 2007 to 2007
$363kInteraction of Retinoid X Receptors and NOD-Like Receptors in Colon InflammationF32DK098916 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI TRUAX, AGNIESZKA DOROTA · 2013 to 2015
$132kNCI NIH HHS F99 CA223019NCI NIH HHS P30 CA016086NCI NIH HHS R01 CA156330NCI NIH HHS T32 CA009156NIAID NIH HHS R01 AI029564NIAID NIH HHS R37 AI029564NIAID NIH HHS R56 AI029564NIDDK NIH HHS F32 DK098916NIDDK NIH HHS P01 DK094779NIDDK NIH HHS P30 DK034987NIDDK NIH HHS P30 DK056350NIDDK NIH HHS T32 DK007737NIH HHS P40 OD010995
Abstract
In addition to high-fat diet (HFD) and inactivity, inflammation and microbiota composition contribute to obesity. Inhibitory immune receptors, such as NLRP12, dampen inflammation and are important for resolving inflammation, but their role in obesity is unknown. We show that obesity in humans correlates with reduced expression of adipose tissue NLRP12. Similarly, Nlrp12
Indexed as
Gastrointestinal MicrobiomeAdipose TissueAdultAgedAnimalsBacteriaFemaleHomeostasisHumansImmunity, InnateIntracellular Signaling Peptides and ProteinsMaleMiceMice, Inbred C57BLMice, KnockoutMiddle AgedIntracellular Signaling Peptides and ProteinsNLRP12 protein, mouseErysipelotrichaceaeinflammasomeinflammationinnate immunityLachnospiraceaemicrobiotaNLRP12obesityshort-chain fatty acidtype 2 diabetes
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.