Evidence map›Paper›PMID 30212643›Full record

ArticleCell host & microbe2018

NLRP12: The Monarch of the Gut.

Hengameh Sadeghi, Suzanne Devkota, Fayyaz S Sutterwala

Open access · bronzeAbstract readComment
PubMed Publisher
In one paragraph

Article in Cell host & microbe, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.1field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 5 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Hengameh SadeghiDepartment of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA; Women's Guild Lung Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
Suzanne DevkotaDepartment of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA; Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
Fayyaz S SutterwalaDepartment of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA; Women's Guild Lung Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA. Electronic address: fayyaz.sutterwala@cshs.org.
Lung Institute · USCedars-Sinai Medical Center · US

Funding

Targeting the NLRP3 inflammasome to limit pathologic sterile inflammationR01AI118719 · NIAID · CEDARS-SINAI MEDICAL CENTER · PI SUTTERWALA, FAYYAZ S. · 2016 to 2020
$2.2M
NIAID NIH HHS R01 AI118719
6 · The paper itself

Abstract

Innate pattern recognition receptors have been implicated in the obesity-associated imbalance of gut microbiota. In this issue of Cell Host & Microbe, Truax et al. (2018) report that NLRP12 prevents high-fat-diet-induced obesity by maintaining beneficial short-chain fatty acid-producing microbiota.

Indexed as

Gastrointestinal MicrobiomeDiet, High-FatHomeostasisHumansImmunity, InnateIntracellular Signaling Peptides and ProteinsObesityIntracellular Signaling Peptides and ProteinsNLRP12 protein, human

Identifiers

PMID30212643
OpenAlexW2891815504

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.