ArticlePLoS pathogens2018
The MAPK kinase BcMkk1 suppresses oxalic acid biosynthesis via impeding phosphorylation of BcRim15 by BcSch9 in Botrytis cinerea.
Article in PLoS pathogens, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 70 citations in OpenAlex.
- The role of induced resistance in mitigating postharvest fungal diseases in fruits and vegetables.Journal of advanced research · 2026Review
- FgNdk1 Promotes Effector Secretion to Scavenge ROS During Fusarium graminearum Infection.Molecular plant pathology · 2025Article
- Biochemical and genetic characterization ofFrontiers in plant science · 2025Article
- Global Analysis of microRNA-like RNAs Reveals Differential Regulation of Pathogenicity and Development inJournal of fungi (Basel, Switzerland) · 2024Article
- SsPtc3 Modulating SsSmk1-MAPK and Autophagy to Facilitate Growth and Pathogenicity in Sclerotinia sclerotiorum.Molecular plant pathology · 2024Article
- Dual RNA-seq reveals distinct families of co-regulated and structurally conserved effectors in Botrytis cinerea infection of Arabidopsis thaliana.BMC biology · 2024Article
- High-quality genome assembly and genetic transformation system ofMicrobiology spectrum · 2024Article
- The Gβ-like protein Bcgbl1 regulates development and pathogenicity of the gray mold Botrytis cinerea via modulating two MAP kinase signaling pathways.PLoS pathogens · 2023Article
- Fused expression of Sm1-Chit42 proteins for synergistic mycoparasitic response of Trichoderma afroharzianum on Botrytis cinerea.Microbial cell factories · 2023Article
- Pathogenic fungi neutralize plant-derived ROS via Srpk1 deacetylation.The EMBO journal · 2023Article
- Enhancement of herbicolin A production by integrated fermentation optimization and strain engineering in Pantoea agglomerans ZJU23.Microbial cell factories · 2023Article
- MPK6-mediated HY5 phosphorylation regulates light-induced anthocyanin accumulation in apple fruit.Plant biotechnology journal · 2023Article
- A dialogue-like cell communication mechanism is conserved in filamentous ascomycete fungi and mediates interspecies interactions.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- The Coupling Between Cell Wall Integrity Mediated by MAPK Kinases and SsFkh1 Is Involved in Sclerotia Formation and Pathogenicity ofFrontiers in microbiology · 2022Article
- Deciphering the Dynamics of Signaling Cascades and Virulence Factors ofMicroorganisms · 2021Article
- Molecular basis of pathogenesis of postharvest pathogenic Fungi and control strategy in fruits: progress and prospect.Molecular horticulture · 2021Review
- Silencing of the Slt2-Type MAP KinaseInternational journal of molecular sciences · 2021Article
- The Destructive Fungal PathogenPathogens (Basel, Switzerland) · 2020Review
- The role of vegetative cell fusions in the development and asexual reproduction of the wheat fungal pathogen Zymoseptoria tritici.BMC biology · 2020Article
- A Single Nucleotide Mutation in Adenylate Cyclase Affects Vegetative Growth, Sclerotial Formation and Virulence ofInternational journal of molecular sciences · 2020Article
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The mitogen-activated protein kinase (MAPK) cassette of the cell wall integrity (CWI) pathway is primarily responsible for orchestrating changes of cell wall. However, functions of this cassette in other cellular processes are not well understood. Here, we found that the Botrytis cinerea mutant of MAPK kinase (BcMkk1) displays more serious defects in mycelial growth, conidiation, responses to cell wall and oxidative stresses, but possesses less reduced virulence than the mutants of its upstream (BcBck1) and downstream (BcBmp3) kinases. Interestingly, BcMkk1, but not BcBck1 and BcBmp3, negatively regulates production of oxalic acid (OA) and activity of extracellular hydrolases (EHs) that are proposed to be virulence factors of B. cinerea. Moreover, we obtained evidence that BcMkk1 negatively controls OA production via impeding phosphorylation of the Per-Arnt-Sim (PAS) kinase BcRim15 by the Ser/Thr kinase BcSch9. In addition, the fungal Pro40 homolog BcPro40 was found to interact simultaneously with three MAPKs, implying that BcPro40 is a scaffold protein of the CWI pathway in B. cinerea. Taken together, results of this study reveal that BcMkk1 negatively modulates virulence via suppressing OA biosynthesis in B. cinerea, which provides novel insight into conserved and species-specific functions of the MAPK kinase in fungi.
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