ArticlePloS one2018
Encoding of locomotion kinematics in the mouse cerebellum.
Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Cerebellar activity is triggered by reach endpoint during learning of a complex locomotor task.Nature communications · 2026Article
- Purkinje Cell Spatial Correlation Dynamics Are Key to Cerebellar Cortical Contributions to Behavior.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Synergistic Reinforcement Learning by Cooperation of the Cerebellum and Basal Ganglia.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Clinical Heterogeneity of Essential Tremor: Understanding Neural Substrates of Action Tremor Subtypes.Cerebellum (London, England) · 2024Review
- Review
- Purkinje cell microzones mediate distinct kinematics of a single movement.Nature communications · 2023Article
- An Improved Surgical Approach for Complete Interhemispheric Corpus Callosotomy Combined with Extended Frontoparietal Craniotomy in Mice.Biomedicines · 2023Article
- Synaptic basis of a sub-second representation of time in a neural circuit model.Nature communications · 2022Article
- Purkinje cell vulnerability induced by diffuse traumatic brain injury is linked to disruption of long-range neuronal circuits.Acta neuropathologica communications · 2022Article
- Gray matter volume of cerebellum associated with idiopathic normal pressure hydrocephalus: A cross-sectional analysis.Frontiers in neurology · 2022Article
- Feature selectivity can explain mismatch signals in mouse visual cortex.Cell reports · 2021Article
- Article
- Article
- Place Cells in Head-Fixed Mice Navigating a Floating Real-World Environment.Frontiers in cellular neuroscience · 2021Article
- Mice Preferentially Use Increases in Cerebral Cortex Spiking to Detect Changes in Visual Stimuli.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Disynaptic cerebrocerebellar pathways originating from multiple functionally distinct cortical areas.eLife · 2020Article
- Article
- Brainstem neurons that command mammalian locomotor asymmetries.Nature neuroscience · 2020Article
- Reward Association Enhances Stimulus-Specific Representations in Primary Visual Cortex.Current biology : CB · 2020Article
- Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
The cerebellum is involved in coordinating motor behaviour, but how the cerebellar network regulates locomotion is still not well understood. We characterised the activity of putative cerebellar Purkinje cells, Golgi cells and mossy fibres in awake mice engaged in an active locomotion task, using high-density silicon electrode arrays. Analysis of the activity of over 300 neurons in response to locomotion revealed that the majority of cells (53%) were significantly modulated by phase of the stepping cycle. However, in contrast to studies involving passive locomotion on a treadmill, we found that a high proportion of cells (45%) were tuned to the speed of locomotion, and 19% were tuned to yaw movements. The activity of neurons in the cerebellar vermis provided more information about future speed of locomotion than about past or present speed, suggesting a motor, rather than purely sensory, role. We were able to accurately decode the speed of locomotion with a simple linear algorithm, with only a relatively small number of well-chosen cells needed, irrespective of cell class. Our observations suggest that behavioural state modulates cerebellar sensorimotor integration, and advocate a role for the cerebellar vermis in control of high-level locomotor kinematic parameters such as speed and yaw.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.