SynthesisPloS one2018
The effects of oral nutritional supplements in patients with maintenance dialysis therapy: A systematic review and meta-analysis of randomized clinical trials.
Synthesis in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04789031 (Muscle Status to Oral Nutritional Supplementation in Hemodialysis Patients With Protein Energy Wasting), which is not on this map. Cited by 38 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Muscle Status to Oral Nutritional Supplementation in Hemodialysis Patients With Protein Energy Wasting
Who cites it
38 citing papers in PubMed, 5 syntheses or guidelines pooled it, 71 citations in OpenAlex.
- Benefits of physical exercises in chronic kidney disease: a systematic review and meta-analysis of randomized controlled trials.Renal failure · 2026Pooled it
- Oral nutritional supplement helps to improve nutritional status of dialysis dependent patients: a systematic review and meta-analysis of randomized controlled trials.Frontiers in nutrition · 2023Pooled it
- Oral nutritional interventions in frail older people who are malnourished or at risk of malnutrition: a systematic review.Health technology assessment (Winchester, England) · 2022Pooled it
- Pooled it
- Oral protein-based supplements versus placebo or no treatment for people with chronic kidney disease requiring dialysis.The Cochrane database of systematic reviews · 2020Pooled it
- The effect of different timings of protein supplementation on variable outcomes in hemodialysis patients: a randomized clinical trial.Clinical and experimental nephrology · 2025Trial
- The impact of predialytic oral protein-based supplements on nutritional status and quality of life in hemodialysis patients: a randomized clinical trial.BMC nephrology · 2025Trial
- The beneficial effects of intradialytic parenteral nutrition in hemodialysis patients with protein energy wasting: a prospective randomized controlled trial.Scientific reports · 2022Trial
- Effectiveness of renal-specific oral nutritional supplements compared with diet counseling in malnourished hemodialysis patients.International urology and nephrology · 2021Trial
- Intradialytic protein supplementation: a comparative study of fish and whey protein on amino acid profiles of patients undergoing hemodialysis.International urology and nephrology · 2026Article
- Homemade formulas for nutrition support in chronic kidney disease: A narrative review of the opportunity for education, research, and innovation.Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition · 2025Review
- Efficacy of intradialytic neuromuscular electrical stimulation and oral nutritional supplementation in hemodialysis patients: a multicenter, randomized controlled trial.Kidney research and clinical practice · 2025Article
- Short-Term Safety of Nutri-Jelly in Adults Undergoing Hemodialysis.Food science & nutrition · 2024Article
- Effects of Nutritional Protocol Changes on Hemodialysis Adequacy and Patient Health During the COVID-19 Pandemic.Medical science monitor : international medical journal of experimental and clinical research · 2024Article
- Questionnaire survey of the frequency of dietary intake during hemodialysis and the impact of COVID-19 in Japan.Clinical and experimental nephrology · 2024Article
- Frailty in hemodialysis patients: results of a screening program and multidisciplinary interventions.Clinical kidney journal · 2023Article
- Effects of oral nutritional supplements on the nutritional status and inflammatory markers in patients on maintenance dialysis: a systematic review and meta-analysis of randomized clinical trials.Clinical kidney journal · 2023Article
- Can Nutrition Contribute to a Reduction in Sarcopenia, Frailty, and Comorbidities in a Super-Aged Society?Nutrients · 2023Review
- Recent Advances in the Nutritional Screening, Assessment, and Treatment of Japanese Patients on Hemodialysis.Journal of clinical medicine · 2023Article
- Effect on nutritional status and biomarkers of inflammation and oxidation of an oral nutritional supplement (with or without probiotics) in malnourished hemodialysis patients. A multicenter randomized clinical trial "Renacare Trial".Frontiers in nutrition · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
objectiveThis systematic review aims to determine the potential effects of oral nutritional supplements (ONS) in patients receiving maintenance dialysis therapy (MDT).
methodsElectronic databases were searched without language limits through to July 2018. Randomized controlled trials (RCTs) that involved comparisons of ONS versus placebo or routine care are included in this meta-analysis. RevMan 5.3 statistical software was used for meta-analysis.
results15 articles with 589 subjects were included in our study. There are insufficient comparable data of randomized trials to allow meta-analysis of mortality. Albumin levels may be improved by the macronutrient blends or protein/amino acid supplements in MDT patients. Compared with the control group, serum albumin levels and BMI in the ONS group were increased by 1.58 g/L (95% CI, 0.52-2.63, P = 0.003; I2 = 85%) and 0.40 kg/m2 (95% CI, 0.10-0.71, P = 0.01; I2 = 49%), respectively. In the subgroup analysis of patients receiving hemodialysis, albumin levels in ONS group were increased by 2.17 g/L (95% CI, 0.89-3.45, P<0.001; I2 = 90%). ONS may not influence serum phosphorus and potassium levels.
conclusionsVery low-quality evidence suggests that Short-term oral energy or protein/amino acid supplements may improve nutritional status by increasing serum albumin levels and BMI in MDT patients, without influence on serum potassium levels. High-quality and large RCTs, particularly regarding the effects of ONS on mortality and quality of life, are needed to further validate our findings.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.