Evidence map›Paper›PMID 30212440›Full record

Observational studyMedical science monitor : international medical journal of experimental and clinical research2018

Plasma Resistin Levels in Patients with Acute Aortic Dissection: A Propensity Score-Matched Observational Case-Control Study.

Xintian Liu, Xuan Zheng, Xi Su, Wei Tian, Yuanping Hu, Zhiping Zhang

Open access · hybridAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Medical science monitor : international medical journal of experimental and clinical research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 2 pooled it
0.6field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 2 syntheses or guidelines pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Observational
  5. Resistin and Cardiac Arrest-A Prospective Study.Journal of clinical medicine · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Xintian LiuDepartment of Cardiology, Wuhan Asia Heart Hospital, Wuhan University of Science and Technology, Wuhan, Hubei, China (mainland).
Xuan ZhengLaboratory of Molecular Cardiology, Wuhan Asia Heart Hospital, Wuhan University of Science and Technology, Wuhan, Hubei, China (mainland).
Xi SuDepartment of Cardiology, Wuhan Asia Heart Hospital, Wuhan University of Science and Technology, Wuhan, Hubei, China (mainland).
Wei TianDepartment of Cardiology, Wuhan Asia Heart Hospital, Wuhan University of Science and Technology, Wuhan, Hubei, China (mainland).
Yuanping HuLaboratory of Molecular Cardiology, Wuhan Asia Heart Hospital, Wuhan University of Science and Technology, Wuhan, Hubei, China (mainland).
Zhiping ZhangDepartment of Cardiology, Wuhan Asia Heart Hospital, Wuhan University of Science and Technology, Wuhan, Hubei, China (mainland).
Wuhan University · CNWuhan Asia Heart Hospital · CNWuhan University of Science and Technology · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND The aim of this observational case-control study was to compare the levels of plasma resistin between patients with acute aortic dissection and matched controls, and to use propensity score matching (PSM) to reduce case selection bias and clinical confounders. MATERIAL AND METHODS With the use of PSM, this study included 43 pairs of patients with acute aortic dissection (type-A and type-B dissection) and matched controls. Plasma resistin levels and other laboratory parameters were compared between the two groups, including white blood cell (WBC) count, glucose, high sensitivity C-reactive protein (hs-CRP), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), and D-dimer. The correlations between resistin and other laboratory parameters were evaluated in patients with acute aortic dissection. RESULTS Following PSM adjustment for clinical variables, including age, sex, body mass index, smoking, alcohol drinking, hypertension, diabetes mellitus, coronary heart disease and stroke, plasma resistin levels were significantly increased in patients with acute aortic dissection when compared with controls (35.2±13.8 vs. 18.4±9.1 ng/ml) (p<0.001). WBC counts, and levels of glucose, hs-CRP, IL-6, TNF-α and D-dimer were also significantly increased in the patients with aortic dissection compared with the control group. After adjustment for these variables, the association between plasma resistin levels and acute aortic dissection remained significant (OR, 1.114; 95% CI, 1.036-1.224) (p<0.001). Plasma resistin levels was positively correlated with WBC count (r=0.368, p=0.015), hs-CRP (r=0.359, p=0.022), IL-6 (r=0.306, p=0.046) and TNF-α levels (r=0.315, p=0.040) in patients with acute aortic dissection. CONCLUSIONS Acute aortic dissection is associated with elevated levels of plasma resistin and other pro-inflammatory cytokines. Plasma resistin levels is positively associated with other pro-inflammatory cytokines in acute aortic dissection.

Indexed as

AdultAgedAortic AneurysmAortic DissectionBiomarkersBlood GlucoseCase-Control StudiesChinaC-Reactive ProteinCross-Sectional StudiesFemaleHumansInterleukin-6Leukocyte CountMaleMiddle AgedBiomarkersBlood GlucoseC-Reactive ProteinInterleukin-6ResistinRETN protein, humanTumor Necrosis Factor-alpha

Identifiers

PMID30212440
PMCPMC6149239
OpenAlexW2892268518

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.