ReviewJournal of applied physiology (Bethesda, Md. : 1985)2018
Intersection between gonadal function and vascular aging in women.
Review in Journal of applied physiology (Bethesda, Md. : 1985), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- Exercise dose and modality for blood pressure reduction in predominantly postmenopausal women: a dose-response network meta-analysis.Frontiers in medicine · 2026Pooled it
- Effects of resveratrol or estradiol on postexercise endothelial function in estrogen-deficient postmenopausal women.Journal of applied physiology (Bethesda, Md. : 1985) · 2020Trial
- Cross-sectional evaluation of anthropometric measures vs MRI-measured visceral and hepatic fat in a Canadian cohort.Journal of the Endocrine Society · 2026Article
- Relations of Menopause Timing With Pressure Pulsatility in the Framingham Study.Hypertension (Dallas, Tex. : 1979) · 2026Article
- Sex differences in blood pressure and hypertension through adulthood.Clinical kidney journal · 2026Article
- Large artery stiffness is elevated in women with a prior pregnancy conceived via in vitro fertilization.Journal of applied physiology (Bethesda, Md. : 1985) · 2026Article
- Exploring Glycocalyx shedding markers: A comparative analysis of plasma markers among premenopausal and postmenopausal women.Physiological reports · 2026Article
- Correlation between ambulatory blood pressure indices and sex hormone imbalance in hypertensive women with different menopausal durations: a cross-sectional study.European journal of medical research · 2026Observational
- Vascular function in women with heart failure with preserved ejection fraction: a mismatch beyond diastole.Journal of applied physiology (Bethesda, Md. : 1985) · 2025Review
- Sex Differences in Cardiovascular Diseases and Vascular Function in Chronic Kidney Disease.Cardiology clinics · 2025Review
- Association between the C-reactive protein-triglyceride glucose index and new-onset coronary heart disease among metabolically heterogeneous individuals.Cardiovascular diabetology · 2025Article
- Assessment of Blood Endothelial Cell Biomarkers in Women and Men with Abnormal Body Mass and Paroxysmal Atrial Fibrillation Based on CHA2DS2-VASC Score: A Retrospective Study.International journal of molecular sciences · 2025Article
- Effects of resistance training intensity on the cardiovascular health of postmenopausal women with hypertension: a study protocol for the LOAD trial.BMJ open sport & exercise medicine · 2025Article
- Age-adjusted visceral adiposity index (VAI) is superior to VAI for predicting mortality among US adults: an analysis of the NHANES 2011-2014.Aging clinical and experimental research · 2024Article
- Article
- Hippocampal glial inflammatory markers are differentially altered in a novel mouse model of perimenopausal cerebral amyloid angiopathy.Frontiers in aging neuroscience · 2023Article
- A Prediction Equation to Estimate Vascular Endothelial Function in Different Body Mass Index Populations.Frontiers in cardiovascular medicine · 2022Article
- Body composition and cardiometabolic health across the menopause transition.Obesity (Silver Spring, Md.) · 2022Review
- Sex Differences in Molecular Mechanisms of Cardiovascular Aging.Frontiers in aging · 2021Review
- Sex Differences in Cardiovascular Aging and Heart Failure.Current heart failure reports · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Vascular aging, characterized by endothelial dysfunction and large elastic arterial stiffening, is a major risk factor for age-associated cardiovascular disease (CVD). Although women have a lower prevalence of CVD until midlife, prevalence rates increase rapidly coincident with the menopausal transition to match those observed in men. The menopausal transition, or perimenopause, is a chaotic period that is associated with increased symptoms (e.g., hot flashes, depressed mood, anxiety, sleep disturbances) and CVD risk factors due to changes in the hormonal environment. Because these quality of life factors and CVD risk factors also change with aging, the arteries of women appear to endure a double insult. Our laboratory has been investigating how changes in gonadal function and hormone levels with the menopause transition impacts the vascular aging process in healthy women. Our work has shown that vascular endothelial function progressively declines, and large elastic arterial stiffness is greater across the stages of the menopausal transition. This acceleration in vascular aging may be due to the loss of vasodilatory, antioxidant, anti-inflammatory, and antiproliferative effects of estradiol on the vascular wall. This minireview discusses the impact of changes in gonadal function and hormones with the menopausal transition on vascular aging in women and areas for investigations to further our understanding of the intersection between gonadal function and vascular aging.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.