ReviewAmerican journal of physiology. Gastrointestinal and liver physiology2018
Eosinophilic esophagitis: pathophysiology and its clinical implications.
Review in American journal of physiology. Gastrointestinal and liver physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 28 citations in OpenAlex.
- Multifocal Giant Granular Cell Tumors of the Alimentary Canal With Concurrent Eosinophilic Gastrointestinal Disease.ACG case reports journal · 2026Article
- Esophageal motility disorders after COVID-19 infection.Scientific reports · 2025Observational
- Cow milk protein allergy mimics in infancy.World journal of clinical pediatrics · 2025Review
- Review
- Nonepithelial Gene Expression Correlates With Symptom Severity in Adults With Eosinophilic Esophagitis.The journal of allergy and clinical immunology. In practice · 2024Article
- Balancing immune responses: regulatory cells in eosinophilic gastrointestinal disorders.Frontiers in immunology · 2024Review
- Immunoglobulin G4 in eosinophilic esophagitis: Immune complex formation and correlation with disease activity.Allergy · 2023Article
- Review
- Adult eosinophilic esophagitis and advances in its treatment.World journal of methodology · 2023Review
- Epithelial-intrinsic defects in TGFβR signaling drive local allergic inflammation manifesting as eosinophilic esophagitis.Science immunology · 2023Article
- High-Resolution Esophageal Manometric Features in Eosinophilic Esophagitis Patients: A Retrospective Study.Gastro hep advances · 2022Article
- Sleep in children with eosinophilic esophagitis.World journal of pediatrics : WJP · 2021Article
- Pathogenesis of Eosinophilic Esophagitis: A Comprehensive Review of the Genetic and Molecular Aspects.International journal of molecular sciences · 2020Review
- Eosinophilic Esophagitis in Children: Clinical Findings and Diagnostic Approach.Current pediatric reviews · 2020Review
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 3 countries.
Funding
Abstract
Classically, eosinophilic esophagitis is an antigen-mediated chronic disease distinct from gastroesophageal reflux disease. Eosinophilic esophagitis is an emerging clinical problem that is growing in recognition. It is characterized clinically by feeding dysfunction, dysphagia, and reflux-like symptoms. Histologically, eosinophilic esophagitis is identifiable by a dense epithelial eosinophilic infiltrate. Experimental modeling and clinical studies over the last decade have greatly improved mechanistic insights and led to improvements in clinical understanding and the assessment of therapeutic options for patients and their clinicians who manage this disease. Here, we review the clinicopathologic diagnostic criteria and our understanding of eosinophilic esophagitis as an allergic disease with genetic and immunological components. We present studies defining the importance of the epithelial barrier and the concept of barrier dysfunction as an initiating or perpetuating factor for this disease. We discuss the relationship between the symptoms of dysphagia and feeding dysfunction, our current knowledge of the underlying pathophysiologic mechanisms, and advances in clinical assessment of esophageal distensibility and narrowing in eosinophilic esophagitis patients. Finally, therapeutic implications relating to the advances that have led to our current understanding of the pathophysiology of eosinophilic esophagitis are explored.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.