Evidence map›Paper›PMID 30211967›Full record

ArticleCytometry. Part A : the journal of the International Society for Analytical Cytology2018

Proteomic Profiling of Native Unpassaged and Culture-Expanded Mesenchymal Stromal Cells (MSC).

Erika Moravcikova, E Michael Meyer, Mirko Corselli, Vera S Donnenberg, Albert D Donnenberg

Abstract read
In one paragraph

Article in Cytometry. Part A : the journal of the International Society for Analytical Cytology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 36 citations in OpenAlex.

  1. Article
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  9. Review
  10. A passage-dependent network for estimating theFrontiers in cell and developmental biology · 2023
    Article
  11. Article
  12. Article
  13. CD105Scientific reports · 2021
    Article
  14. Article
  15. Review
  16. Roles of mesenchymal stromal cells in the head and neck cancer microenvironment.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2021
    Review
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 1 country.

Erika MoravcikovaDepartment of Cardiothoracic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
E Michael MeyerUniversity of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania.
Mirko CorselliBD Biosciences, La Jolla, California.
Vera S DonnenbergDepartment of Cardiothoracic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
Albert D DonnenbergUniversity of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania.
UPMC Hillman Cancer Center · USBD Biosciences (United States) · USMcGowan Institute for Regenerative Medicine · USUniversity of Pittsburgh · US

Funding

VECTOR CORE FACILITYP30CA047904 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI JOHN C. BYRD · 1988 to 2026
$158.0M
Injectable Engineered Tissue for Cancer ReconstructionR01CA114246 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI RUBIN, J PETER · 2006 to 2019
$3.3M
Micro-scale analysis of mesenchymal to epithelial transition in lung cancerR21CA191647 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI DONNENBERG, ALBERT D · 2015 to 2016
$382k
NCI NIH HHS P30 CA047904NCI NIH HHS R01 CA114246NCI NIH HHS R21 CA191647
6 · The paper itself

Abstract

Human culture-expanded mesenchymal stromal cells (MSC) are being considered for multiple therapeutic applications because of their regenerative and anti-inflammatory properties. Although a large number of MSC can be propagated from a small initial sample, several lines of evidence indicate that MSC lose their immunosuppressive and regenerative potency aftaer multiple passages. In this report, we use the FACSCAP Lyoplate proteomic analysis system to detect changes in cell surface protein expression of CD45

Indexed as

AdipogenesisAntigens, CDBone MarrowBone Marrow CellsCell DifferentiationCell ProliferationCells, CulturedHumansMesenchymal Stem CellsOsteogenesisProteomeProteomicsStromal CellsAntigens, CDProteomeadipogenesisbone marrowCD105CD73Lyoplatemesenchymal stem cellsosteogenesisproteomicunpassaged bone marrow MSC

Identifiers

PMID30211967
PMCPMC6192517
OpenAlexW2892367700

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.