ArticleNeuropsychology2018
Intraindividual variability in neuropsychological performance predicts cognitive decline and death in HIV.
Article in Neuropsychology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
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Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Applications of Machine Learning for Cognitive Health in Older Individuals With HIV: Rapid Systematic Review.JMIR aging · 2025Pooled it
- Cognitive intra-individual variability in breast cancer survivors: A systematic review.Applied neuropsychology. AdultPooled it
- Exploring the potential of cognitive intra-individual variability in HIV care and research in adults with HIV: a concept analysis.Applied neuropsychology. Adult · 2026Review
- Examining the Stability and Predictive Utility of Across- and Within-Domain Intra-Individual Variability in Mild Cognitive Impairment.Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists · 2025Article
- HIV Stigma is Associated with Two-Year Decline in Cognitive Performance Among People with HIV.AIDS and behavior · 2025Article
- Does cognitive intra-individual variability predict change in everyday functioning performance in women with and without HIV in the Women's Interagency HIV Study?Applied neuropsychology. Adult · 2024Article
- Cognitive dispersion and its functional relevance in behavioral variant frontotemporal dementia and prodromal behavioral variant frontotemporal dementia.Neuropsychology · 2024Article
- Self-perceived cognitive fluctuations and their relationship to everyday functioning in older adults with and without HIV disease.The Clinical neuropsychologist · 2024Article
- Recent Advances in Neuropsychological Test Interpretation for Clinical Practice.Neuropsychology review · 2024Review
- Cognitive Intra-Individual Variability as an Outcome or Moderator of Speed of Processing Training in Aging Adults with HIV-Associated Neurocognitive Disorder: A Secondary Data Analysis of a 2-Year Longitudinal Randomized Clinical Trial.Archives of gerontology and geriatrics plus · 2024Article
- Digital Neuropsychology beyond Computerized Cognitive Assessment: Applications of Novel Digital Technologies.Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists · 2024Review
- Beyond the Global Brain Differences: Intraindividual Variability Differences in 1q21.1 Distal and 15q11.2 BP1-BP2 Deletion Carriers.Biological psychiatry · 2024Article
- Computer use: a protective factor for cognition in aging and HIV disease?Aging clinical and experimental research · 2023Article
- Lower prospective memory is associated with higher neurocognitive dispersion in two samples of people with HIV: A conceptual replication study.Journal of the International Neuropsychological Society : JINS · 2023Article
- Moving intra-individual variability (IIV) towards clinical utility: IIV measured using a commercial testing platform.Journal of the neurological sciences · 2023Article
- Cognitive Intra-individual Variability in HIV: an Integrative Review.Neuropsychology review · 2022Review
- Intraindividual variability in neuropsychological performance predicts longitudinal cortical volume loss in early Parkinson's disease.Neuropsychology · 2022Article
- Neurocognitive status and risk of mortality among people living with human immunodeficiency virus: an 18-year retrospective cohort study.Scientific reports · 2021Article
- Beyond PD-MCI: objectively defined subtle cognitive decline predicts future cognitive and functional changes.Journal of neurology · 2021Article
- Using neuronal extracellular vesicles and machine learning to predict cognitive deficits in HIV.Journal of neurovirology · 2020Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
objectiveHIV-associated neurocognitive disorder (HAND) occurs in a significant percentage of HIV-infected (HIV+) adults. Increased intraindividual variability (IIV) in cognitive function may be an early marker of emerging neurocognitive disorder, which suggests that IIV may be a sensitive measure of neurologic compromise in HIV. In the current study, we hypothesize that increased IIV may predict impending morbidity, including future cognitive decline and death.
methodIn 708 HIV+ participants followed longitudinally for up to 14 years, we assessed the role of dispersion in forecasting death and cognitive decline. Incident neurocognitive impairment was predicted in a mixed-effects ordinal logistic regression model using age, gender, baseline mean cognitive functioning, CD4+, time followed, years of education, and dispersion at the previous visit. Death before the next visit was predicted in a binomial mixed-effects regression model using age, gender, baseline mean cognitive functioning, CD4+, time followed, years of education, and dispersion.
resultsPoint-in-time dispersion and change in dispersion between visits predict future cognitive decline and death in HIV+ individuals. Individuals with greater dispersion at a visit or who had larger changes in dispersion between visits were more likely to demonstrate greater neurocognitive impairment at the subsequent visit. Greater IIV was also associated with an increased risk of death prior to the subsequent visit, even after controlling for HAND severity and global cognitive functioning.
conclusionsWe conclude that the IIV in cognitive functioning may be more predictive of future disease consequence than mean level of cognitive functioning. (PsycINFO Database Record (c) 2018 APA, all rights reserved).
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