Evidence map›Paper›PMID 30211544›Full record

ArticleBiochemistry2018

Human eIF5 and eIF1A Compete for Binding to eIF5B.

Kai Ying Lin, Nabanita Nag, Tatyana V Pestova, Assen Marintchev

Open access · greenAbstract read
In one paragraph

Article in Biochemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 24 citations in OpenAlex.

  1. Review
  2. eIF1 and eIF5 dynamically control translation start site fidelity.Nature structural & molecular biology · 2025
    Article
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  10. Review
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  13. Long-range interdomain communications in eIF5B regulate GTP hydrolysis and translation initiation.Proceedings of the National Academy of Sciences of the United States of America · 2020
    Article
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  15. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Kai Ying LinDepartment of Physiology & Biophysics , Boston University School of Medicine , Boston , Massachusetts 02118 , United States.
Nabanita NagDepartment of Physiology & Biophysics , Boston University School of Medicine , Boston , Massachusetts 02118 , United States.
Tatyana V PestovaDepartment of Cell Biology , State University of New York, Downstate Medical Center , Brooklyn , New York 11203 , United States.
Assen MarintchevDepartment of Physiology & Biophysics , Boston University School of Medicine , Boston , Massachusetts 02118 , United States.ORCID 0000-0002-9901-3500
Boston University · USState University of New York · US

Funding

Mechanisms of eukaryotic translation and ribosome-associated mRNA surveillance and protein quality controlR35GM122602 · NIGMS · SUNY DOWNSTATE MEDICAL CENTER · PI TATYANA V PESTOVA · 2017 to 2026
$4.8M
Mechanisms of assembly and remodeling of human translation initiation complexesR01GM095720 · NIGMS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI MARINTCHEV, ASSEN G · 2011 to 2015
$1.5M
NIGMS NIH HHS R01 GM095720NIGMS NIH HHS R35 GM122602
6 · The paper itself

Abstract

Eukaryotic translation initiation is a multistep process requiring a number of eukaryotic translation initiation factors (eIFs). Two GTPases play key roles in the process. eIF2 brings the initiator Met-tRNA

Indexed as

Eukaryotic Initiation FactorsGuanosine TriphosphateHumansNeoplasm ProteinsNerve Tissue ProteinsProtein BindingRibosomesRNA, Transfer, Amino AcylEIF1 protein, humaneukaryotic initiation factor-5BEukaryotic Initiation FactorsGuanosine TriphosphateNeoplasm ProteinsNerve Tissue ProteinsRNA, Transfer, Amino Acyl

Identifiers

PMID30211544
PMCPMC6177315
OpenAlexW2891239287

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.