Evidence map›Paper›PMID 30211447›Full record

ArticleThe Journal of physiology2018

Ventilatory and integrated physiological responses to chronic hypercapnia in goats.

Nicholas J Burgraff, Suzanne E Neumueller, Kirstyn Buchholz, Thomas M Langer, Matthew R Hodges, Lawrence Pan, Hubert V Forster

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 26 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
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  5. Article
  6. Ventilatory neural drive in chronically hypercapnic patients with COPD: effects of sleep and nocturnal noninvasive ventilation.European respiratory review : an official journal of the European Respiratory Society · 2022
    Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Brainstem serotonergic, catecholaminergic, and inflammatory adaptations during chronic hypercapnia in goats.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019
    Article
  13. Article
  14. Article
  15. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Nicholas J BurgraffDepartment of Physiology, Medical College of Wisconsin, Milwaukee, WI, USA.
Suzanne E NeumuellerDepartment of Physiology, Medical College of Wisconsin, Milwaukee, WI, USA.
Kirstyn BuchholzDepartment of Physiology, Medical College of Wisconsin, Milwaukee, WI, USA.
Thomas M LangerDepartment of Physiology, Medical College of Wisconsin, Milwaukee, WI, USA.
Matthew R HodgesDepartment of Physiology, Medical College of Wisconsin, Milwaukee, WI, USA.ORCID 0000-0002-1692-9055
Lawrence PanDepartment of Physical Therapy, Marquette University, Milwaukee, WI, USA.
Hubert V ForsterDepartment of Physiology, Medical College of Wisconsin, Milwaukee, WI, USA.
Medical College of Wisconsin · USMarquette University · US

Funding

INTEGRATED PHYSIOLOGY TRAINING--MOLECULE TO ORGANISMT32HL007852 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI Matthew Robert Hodges · 1996 to 2026
$6.5M
Progressive seizure-induced cardiorespiratory dysfunction in a novel mutant rat model of seizure disorderR01HL122358 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI HODGES, MATTHEW ROBERT · 2015 to 2024
$4.3M
Mechanisms of Ventilatory Adaptations to Chronic HypercapniaI01BX003284 · VA · CLEMENT J. ZABLOCKI VA MEDICAL CENTER · PI FORSTER, HUBERT V · 2016 to 2024
–
BLRD VA I01 BX003284NHLBI NIH HHS R01 HL122358NHLBI NIH HHS T32 HL007852
6 · The paper itself

Abstract

key pointsChronic hypercapnia per se has distinct effects on the mechanisms regulating steady-state ventilation and the CO ABSTRACT: Respiratory diseases such as chronic obstructive pulmonary disease (COPD) often lead to chronic hypercapnia which may exacerbate progression of the disease, increase risk of mortality and contribute to comorbidities such as cognitive dysfunction. Determining the contribution of hypercapnia per se to adaptations in ventilation and cognitive dysfunction within this patient population is complicated by the presence of multiple comorbidities. Herein, we sought to determine the role of chronic hypercapnia per se on the temporal pattern of ventilation and the ventilatory CO

Indexed as

Adaptation, PhysiologicalAnimalsCarbon DioxideCognitionFemaleGoatsHypercapniaReflexRespirationRespiratory MechanicsCarbon DioxideChemoreflexCognitionHypercapnia

Identifiers

PMID30211447
PMCPMC6235946
OpenAlexW2896871049

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.