Evidence map›Paper›PMID 30211307›Full record

RevieweNeuro

A Tutorial for Information Theory in Neuroscience.

Nicholas M Timme, Christopher Lapish

Abstract readReview
In one paragraph

Review in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 111 papers.

0numbers the graph read from it
0cells of the map it votes in
111citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

111 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Neural substrate of conditioned stimulus for associative learning in the hippocampus.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  11. Revisiting alpha-theta cross-frequency dynamics during working memory.Cerebral cortex (New York, N.Y. : 1991) · 2026
    Article
  12. Article
  13. Article
  14. Article
  15. Neurodatascience: Past, Present, and Future.Data science in science · 2026
    Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article

51 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Nicholas M TimmeDepartment of Psychology, Indiana University - Purdue University Indianapolis, 402 N. Blackford St, Indianapolis, IN 46202.
Christopher LapishDepartment of Psychology, Indiana University - Purdue University Indianapolis, 402 N. Blackford St, Indianapolis, IN 46202.

Funding

Translational Research and Science Education (OUT)P60AA007611 · NIAAA · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI DAVID A. KAREKEN · 2003 to 2026
$45.5M
TRAINING GRANT ON GENETICS ASPECTS OF ALCOHOLISMT32AA007462 · NIAAA · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI CRISTINE L CZACHOWSKI · 1985 to 2026
$10.7M
NIAAA NIH HHS P60 AA007611NIAAA NIH HHS T32 AA007462
6 · The paper itself

Abstract

Understanding how neural systems integrate, encode, and compute information is central to understanding brain function. Frequently, data from neuroscience experiments are multivariate, the interactions between the variables are nonlinear, and the landscape of hypothesized or possible interactions between variables is extremely broad. Information theory is well suited to address these types of data, as it possesses multivariate analysis tools, it can be applied to many different types of data, it can capture nonlinear interactions, and it does not require assumptions about the structure of the underlying data (i.e., it is model independent). In this article, we walk through the mathematics of information theory along with common logistical problems associated with data type, data binning, data quantity requirements, bias, and significance testing. Next, we analyze models inspired by canonical neuroscience experiments to improve understanding and demonstrate the strengths of information theory analyses. To facilitate the use of information theory analyses, and an understanding of how these analyses are implemented, we also provide a free MATLAB software package that can be applied to a wide range of data from neuroscience experiments, as well as from other fields of study.

Indexed as

Information TheoryNeurosciencesAction PotentialsAnimalsBrainComputer SimulationData Interpretation, StatisticalHumansNeuronsSoftwareInformation flowinformation theorymutual informationneural computationneural encodingtransfer entropy

Identifiers

PMID30211307
PMCPMC6131830

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.