ArticleNeurology(R) neuroimmunology & neuroinflammation2018
Physical activity and dentate gyrus volume in pediatric acquired demyelinating syndromes.
Registry-linked trialOpen access · goldAbstract read
In one paragraph
Article in Neurology(R) neuroimmunology & neuroinflammation, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06870968 (An Exercise Training Intervention for Depressive Symptoms in Youth With MS), which is not on this map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 33% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
An Exercise Training Intervention for Depressive Symptoms in Youth With MS: A Randomized Controlled Feasibility Trial
Who cites it
1 citing paper in PubMed, 4 citations in OpenAlex.
- Anatomical variations of the dentate gyrus in normal adult brain.Surgical and radiologic anatomy : SRA · 2020Article
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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 4 institutions in 2 countries.
Giulia LongoniDivision of Neurology, Department of Neurosciences and Mental Health (G.L., S.A.G., E.A.Y.), the Hospital for Sick Children, Toronto, ON, Canada; Department of Pediatrics (G.L., H.M.B., E.A.Y.), the University of Toronto, Toronto, ON, Canada; McConnell Brain Imaging Centre (R.A.B., B.A.-B., D.F., D.L.C., S.N., D.L.A.), Montreal Neurological Institute and Hospital, McGill University, Montreal, QC, Canada; Division of Medical Imaging (H.M.B.), the Hospital for Sick Children, Toronto, ON, Canada; Department of Physical Therapy (R.W.M.), University of Alabama at Birmingham, Birmingham, AL; Departments of Internal Medicine and Community Health Sciences (R.A.M.), Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Manitoba, Canada; and Division of Neurology (B.B.), the Children's Hospital of Philadelphia, Perelman School of Medicine (A.B.-O.), University of Pennsylvania, Philadelphia, PA.
Robert A BrownDivision of Neurology, Department of Neurosciences and Mental Health (G.L., S.A.G., E.A.Y.), the Hospital for Sick Children, Toronto, ON, Canada; Department of Pediatrics (G.L., H.M.B., E.A.Y.), the University of Toronto, Toronto, ON, Canada; McConnell Brain Imaging Centre (R.A.B., B.A.-B., D.F., D.L.C., S.N., D.L.A.), Montreal Neurological Institute and Hospital, McGill University, Montreal, QC, Canada; Division of Medical Imaging (H.M.B.), the Hospital for Sick Children, Toronto, ON, Canada; Department of Physical Therapy (R.W.M.), University of Alabama at Birmingham, Birmingham, AL; Departments of Internal Medicine and Community Health Sciences (R.A.M.), Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Manitoba, Canada; and Division of Neurology (B.B.), the Children's Hospital of Philadelphia, Perelman School of Medicine (A.B.-O.), University of Pennsylvania, Philadelphia, PA.
Berengere Aubert-BrocheDivision of Neurology, Department of Neurosciences and Mental Health (G.L., S.A.G., E.A.Y.), the Hospital for Sick Children, Toronto, ON, Canada; Department of Pediatrics (G.L., H.M.B., E.A.Y.), the University of Toronto, Toronto, ON, Canada; McConnell Brain Imaging Centre (R.A.B., B.A.-B., D.F., D.L.C., S.N., D.L.A.), Montreal Neurological Institute and Hospital, McGill University, Montreal, QC, Canada; Division of Medical Imaging (H.M.B.), the Hospital for Sick Children, Toronto, ON, Canada; Department of Physical Therapy (R.W.M.), University of Alabama at Birmingham, Birmingham, AL; Departments of Internal Medicine and Community Health Sciences (R.A.M.), Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Manitoba, Canada; and Division of Neurology (B.B.), the Children's Hospital of Philadelphia, Perelman School of Medicine (A.B.-O.), University of Pennsylvania, Philadelphia, PA.
Stephanie A GroverDivision of Neurology, Department of Neurosciences and Mental Health (G.L., S.A.G., E.A.Y.), the Hospital for Sick Children, Toronto, ON, Canada; Department of Pediatrics (G.L., H.M.B., E.A.Y.), the University of Toronto, Toronto, ON, Canada; McConnell Brain Imaging Centre (R.A.B., B.A.-B., D.F., D.L.C., S.N., D.L.A.), Montreal Neurological Institute and Hospital, McGill University, Montreal, QC, Canada; Division of Medical Imaging (H.M.B.), the Hospital for Sick Children, Toronto, ON, Canada; Department of Physical Therapy (R.W.M.), University of Alabama at Birmingham, Birmingham, AL; Departments of Internal Medicine and Community Health Sciences (R.A.M.), Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Manitoba, Canada; and Division of Neurology (B.B.), the Children's Hospital of Philadelphia, Perelman School of Medicine (A.B.-O.), University of Pennsylvania, Philadelphia, PA.
Helen M BransonDivision of Neurology, Department of Neurosciences and Mental Health (G.L., S.A.G., E.A.Y.), the Hospital for Sick Children, Toronto, ON, Canada; Department of Pediatrics (G.L., H.M.B., E.A.Y.), the University of Toronto, Toronto, ON, Canada; McConnell Brain Imaging Centre (R.A.B., B.A.-B., D.F., D.L.C., S.N., D.L.A.), Montreal Neurological Institute and Hospital, McGill University, Montreal, QC, Canada; Division of Medical Imaging (H.M.B.), the Hospital for Sick Children, Toronto, ON, Canada; Department of Physical Therapy (R.W.M.), University of Alabama at Birmingham, Birmingham, AL; Departments of Internal Medicine and Community Health Sciences (R.A.M.), Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Manitoba, Canada; and Division of Neurology (B.B.), the Children's Hospital of Philadelphia, Perelman School of Medicine (A.B.-O.), University of Pennsylvania, Philadelphia, PA.
Dumitru FetcoDivision of Neurology, Department of Neurosciences and Mental Health (G.L., S.A.G., E.A.Y.), the Hospital for Sick Children, Toronto, ON, Canada; Department of Pediatrics (G.L., H.M.B., E.A.Y.), the University of Toronto, Toronto, ON, Canada; McConnell Brain Imaging Centre (R.A.B., B.A.-B., D.F., D.L.C., S.N., D.L.A.), Montreal Neurological Institute and Hospital, McGill University, Montreal, QC, Canada; Division of Medical Imaging (H.M.B.), the Hospital for Sick Children, Toronto, ON, Canada; Department of Physical Therapy (R.W.M.), University of Alabama at Birmingham, Birmingham, AL; Departments of Internal Medicine and Community Health Sciences (R.A.M.), Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Manitoba, Canada; and Division of Neurology (B.B.), the Children's Hospital of Philadelphia, Perelman School of Medicine (A.B.-O.), University of Pennsylvania, Philadelphia, PA.
Amit Bar-OrDivision of Neurology, Department of Neurosciences and Mental Health (G.L., S.A.G., E.A.Y.), the Hospital for Sick Children, Toronto, ON, Canada; Department of Pediatrics (G.L., H.M.B., E.A.Y.), the University of Toronto, Toronto, ON, Canada; McConnell Brain Imaging Centre (R.A.B., B.A.-B., D.F., D.L.C., S.N., D.L.A.), Montreal Neurological Institute and Hospital, McGill University, Montreal, QC, Canada; Division of Medical Imaging (H.M.B.), the Hospital for Sick Children, Toronto, ON, Canada; Department of Physical Therapy (R.W.M.), University of Alabama at Birmingham, Birmingham, AL; Departments of Internal Medicine and Community Health Sciences (R.A.M.), Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Manitoba, Canada; and Division of Neurology (B.B.), the Children's Hospital of Philadelphia, Perelman School of Medicine (A.B.-O.), University of Pennsylvania, Philadelphia, PA.
Ruth Ann MarrieDivision of Neurology, Department of Neurosciences and Mental Health (G.L., S.A.G., E.A.Y.), the Hospital for Sick Children, Toronto, ON, Canada; Department of Pediatrics (G.L., H.M.B., E.A.Y.), the University of Toronto, Toronto, ON, Canada; McConnell Brain Imaging Centre (R.A.B., B.A.-B., D.F., D.L.C., S.N., D.L.A.), Montreal Neurological Institute and Hospital, McGill University, Montreal, QC, Canada; Division of Medical Imaging (H.M.B.), the Hospital for Sick Children, Toronto, ON, Canada; Department of Physical Therapy (R.W.M.), University of Alabama at Birmingham, Birmingham, AL; Departments of Internal Medicine and Community Health Sciences (R.A.M.), Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Manitoba, Canada; and Division of Neurology (B.B.), the Children's Hospital of Philadelphia, Perelman School of Medicine (A.B.-O.), University of Pennsylvania, Philadelphia, PA.
Robert W MotlDivision of Neurology, Department of Neurosciences and Mental Health (G.L., S.A.G., E.A.Y.), the Hospital for Sick Children, Toronto, ON, Canada; Department of Pediatrics (G.L., H.M.B., E.A.Y.), the University of Toronto, Toronto, ON, Canada; McConnell Brain Imaging Centre (R.A.B., B.A.-B., D.F., D.L.C., S.N., D.L.A.), Montreal Neurological Institute and Hospital, McGill University, Montreal, QC, Canada; Division of Medical Imaging (H.M.B.), the Hospital for Sick Children, Toronto, ON, Canada; Department of Physical Therapy (R.W.M.), University of Alabama at Birmingham, Birmingham, AL; Departments of Internal Medicine and Community Health Sciences (R.A.M.), Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Manitoba, Canada; and Division of Neurology (B.B.), the Children's Hospital of Philadelphia, Perelman School of Medicine (A.B.-O.), University of Pennsylvania, Philadelphia, PA.
D Louis CollinsDivision of Neurology, Department of Neurosciences and Mental Health (G.L., S.A.G., E.A.Y.), the Hospital for Sick Children, Toronto, ON, Canada; Department of Pediatrics (G.L., H.M.B., E.A.Y.), the University of Toronto, Toronto, ON, Canada; McConnell Brain Imaging Centre (R.A.B., B.A.-B., D.F., D.L.C., S.N., D.L.A.), Montreal Neurological Institute and Hospital, McGill University, Montreal, QC, Canada; Division of Medical Imaging (H.M.B.), the Hospital for Sick Children, Toronto, ON, Canada; Department of Physical Therapy (R.W.M.), University of Alabama at Birmingham, Birmingham, AL; Departments of Internal Medicine and Community Health Sciences (R.A.M.), Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Manitoba, Canada; and Division of Neurology (B.B.), the Children's Hospital of Philadelphia, Perelman School of Medicine (A.B.-O.), University of Pennsylvania, Philadelphia, PA.
Sridar NarayananDivision of Neurology, Department of Neurosciences and Mental Health (G.L., S.A.G., E.A.Y.), the Hospital for Sick Children, Toronto, ON, Canada; Department of Pediatrics (G.L., H.M.B., E.A.Y.), the University of Toronto, Toronto, ON, Canada; McConnell Brain Imaging Centre (R.A.B., B.A.-B., D.F., D.L.C., S.N., D.L.A.), Montreal Neurological Institute and Hospital, McGill University, Montreal, QC, Canada; Division of Medical Imaging (H.M.B.), the Hospital for Sick Children, Toronto, ON, Canada; Department of Physical Therapy (R.W.M.), University of Alabama at Birmingham, Birmingham, AL; Departments of Internal Medicine and Community Health Sciences (R.A.M.), Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Manitoba, Canada; and Division of Neurology (B.B.), the Children's Hospital of Philadelphia, Perelman School of Medicine (A.B.-O.), University of Pennsylvania, Philadelphia, PA.
Douglas L ArnoldDivision of Neurology, Department of Neurosciences and Mental Health (G.L., S.A.G., E.A.Y.), the Hospital for Sick Children, Toronto, ON, Canada; Department of Pediatrics (G.L., H.M.B., E.A.Y.), the University of Toronto, Toronto, ON, Canada; McConnell Brain Imaging Centre (R.A.B., B.A.-B., D.F., D.L.C., S.N., D.L.A.), Montreal Neurological Institute and Hospital, McGill University, Montreal, QC, Canada; Division of Medical Imaging (H.M.B.), the Hospital for Sick Children, Toronto, ON, Canada; Department of Physical Therapy (R.W.M.), University of Alabama at Birmingham, Birmingham, AL; Departments of Internal Medicine and Community Health Sciences (R.A.M.), Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Manitoba, Canada; and Division of Neurology (B.B.), the Children's Hospital of Philadelphia, Perelman School of Medicine (A.B.-O.), University of Pennsylvania, Philadelphia, PA.
Brenda BanwellDivision of Neurology, Department of Neurosciences and Mental Health (G.L., S.A.G., E.A.Y.), the Hospital for Sick Children, Toronto, ON, Canada; Department of Pediatrics (G.L., H.M.B., E.A.Y.), the University of Toronto, Toronto, ON, Canada; McConnell Brain Imaging Centre (R.A.B., B.A.-B., D.F., D.L.C., S.N., D.L.A.), Montreal Neurological Institute and Hospital, McGill University, Montreal, QC, Canada; Division of Medical Imaging (H.M.B.), the Hospital for Sick Children, Toronto, ON, Canada; Department of Physical Therapy (R.W.M.), University of Alabama at Birmingham, Birmingham, AL; Departments of Internal Medicine and Community Health Sciences (R.A.M.), Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Manitoba, Canada; and Division of Neurology (B.B.), the Children's Hospital of Philadelphia, Perelman School of Medicine (A.B.-O.), University of Pennsylvania, Philadelphia, PA.
E Ann YehDivision of Neurology, Department of Neurosciences and Mental Health (G.L., S.A.G., E.A.Y.), the Hospital for Sick Children, Toronto, ON, Canada; Department of Pediatrics (G.L., H.M.B., E.A.Y.), the University of Toronto, Toronto, ON, Canada; McConnell Brain Imaging Centre (R.A.B., B.A.-B., D.F., D.L.C., S.N., D.L.A.), Montreal Neurological Institute and Hospital, McGill University, Montreal, QC, Canada; Division of Medical Imaging (H.M.B.), the Hospital for Sick Children, Toronto, ON, Canada; Department of Physical Therapy (R.W.M.), University of Alabama at Birmingham, Birmingham, AL; Departments of Internal Medicine and Community Health Sciences (R.A.M.), Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Manitoba, Canada; and Division of Neurology (B.B.), the Children's Hospital of Philadelphia, Perelman School of Medicine (A.B.-O.), University of Pennsylvania, Philadelphia, PA.
University of Manitoba · CAUniversity of Alabama at Birmingham · USUniversity of Toronto · CAHospital for Sick Children · CA
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo assess the association between daily moderate-to-vigorous physical activity (MVPA) and dentate gyrus volume (DGv) in pediatric patients with acquired demyelinating syndromes (ADSs) of the CNS.
methodsCross-sectional analysis of accelerometry (7 days) and research protocol MRI data from 12 pediatric MS and 18 children with monophasic ADS (monoADS). Total brain and DGv were quantified using standardized methods. The association of daily minutes of MVPA with normalized DGv (nDGv) was assessed using multivariable generalized linear models.
resultsMedian (interquartile range) MVPA was lower in MS patients [9.5 (14)] and exhibited less variation than in monoADS patients [24.5 (47)]. nDGv did not differ significantly between groups [mean nDGv (SD) [cm
conclusionsHigher MVPA associates with greater nDGv in children who have recovered from monophasic demyelination. Larger studies are required to determine whether MVPA can promote regional brain development, or limit tissue damage, in youth with MS.
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Registered trials
NCT06870968ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.