ReviewJournal of immunology research2018
Audiovestibular Symptoms in Systemic Autoimmune Diseases.
Review in Journal of immunology research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
39 citing papers in PubMed, 3 syntheses or guidelines pooled it, 85 citations in OpenAlex.
- Audiovestibular symptoms in systemic sclerosis: a systematic review and meta-analysis.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2025Pooled it
- Hearing impairment in systemic sclerosis patients-what do we really know?Frontiers in medicine · 2024Pooled it
- Secondary autoimmune immune ear disease (AIED): a systematic review and meta-analysis on vestibular manifestations of systemic autoimmune and inflammatory disorders.Clinical rheumatology · 2023Pooled it
- Cochlear Implantation in Autoimmune Inner-Ear Disease: Outcome and Patient-Reported Benefit.The Laryngoscope · 2026Article
- Autoimmune Diseases and the Vestibular and Oculomotor System: Clinical Presentation, Diagnosis, and Treatment.Journal of eye movement research · 2026Review
- Vestibular Involvement in Systemic Autoimmune and Rheumatologic Diseases: A Systematic Review and GRADE-Based Assessment.Journal of clinical medicine · 2026Review
- Assessment of Macular Choroidal Thickness via Enhanced Depth Imaging Optical Coherence Tomography in Patients With Chronic Tinnitus.Journal of ophthalmology · 2026Article
- Immune-mediated cochleovestibular dysfunction: clinical spectrum from isolated inner-ear disorders to systemic autoimmune diseases and therapeutic strategies.Frontiers in immunology · 2026Review
- Association Between Hearing Loss and Systemic Small-Vessel Vasculitis: Audiological Aspects Across Disease Types.Medicina (Kaunas, Lithuania) · 2025Article
- Exploring How Blood Cell Levels Influence Subjective Tinnitus: A Cross-Sectional Case-Control Study.Audiology research · 2025Article
- Tinnitus and Its Comorbidities: A Comprehensive Analysis of Their Relationships.Journal of clinical medicine · 2025Article
- Comparison of GWAS results between de novo tinnitus and cancer treatment-related tinnitus suggests distinctive roles for genetic risk factors.Scientific reports · 2024Article
- Audiovestibular Dysfunction in Systemic Lupus Erythematosus Patients: A Systematic Review.Diagnostics (Basel, Switzerland) · 2024Review
- Prevalence of hearing loss, tinnitus, vertigo and sudden deafness among patients with polymyositis and dermatomyositis.Scientific reports · 2024Article
- Audiological Manifestations in Patients with Granulomatosis with Polyangiitis.Medicina (Kaunas, Lithuania) · 2024Article
- A Retrospective Study of Clinical Profile of Patients with Autoimmune Inner Ear Disease.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2024Article
- Associations of Tinnitus Incidence with Use of Tumor Necrosis Factor-Alpha Inhibitors among Patients with Autoimmune Conditions.Journal of clinical medicine · 2023Article
- The Prevalence of Hearing Impairments in Women with Silicone Breast Implants.Diseases (Basel, Switzerland) · 2023Article
- Comorbidities and laboratory changes of sudden sensorineural hearing loss: a review.Frontiers in neurology · 2023Review
- Sensorineural Hearing Loss in Sjögren's Syndrome.International journal of molecular sciences · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Immune-mediated inner ear disease can be primary, when the autoimmune response is against the inner ear, or secondary. The latter is characterized by the involvement of the ear in the presence of systemic autoimmune conditions. Sensorineural hearing loss is the most common audiovestibular symptom associated with systemic autoimmune diseases, although conductive hearing impairment may also be present. Hearing loss may present in a sudden, slowly, rapidly progressive or fluctuating form, and is mostly bilateral and asymmetric. Hearing loss shows a good response to corticosteroid therapy that may lead to near-complete hearing restoration. Vestibular symptoms, tinnitus, and aural fullness can be found in patients with systemic autoimmune diseases; they often mimic primary inner ear disorders such as Menière's disease and mainly affect both ears simultaneously. Awareness of inner ear involvement in systemic autoimmune diseases is essential for the good response shown to appropriate treatment. However, it is often misdiagnosed due to variable clinical presentation, limited knowledge, sparse evidence, and lack of specific diagnostic tests. The aim of this review is to analyse available evidence, often only reported in the form of case reports due to the rarity of some of these conditions, of the different clinical presentations of audiological and vestibular symptoms in systemic autoimmune diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.