ArticleWorld journal of clinical cases2018
Impact of sorafenib on epidural fibrosis: An immunohistochemical study.
Article in World journal of clinical cases, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed, 7 citations in OpenAlex.
- The Antifibrotic Effects of Plasminogen Activator Inhibitor-1 Antagonists are Observed in Rats with Epidural Fibrosis.Sisli Etfal Hastanesi tip bulteni · 2025Article
- Impact of radial extracorporeal shock wave therapy in post-laminectomy epidural fibrosis in a rat model.Joint diseases and related surgery · 2021Article
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Authors and funding
8 authors at 5 institutions in 2 countries.
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No grant is acknowledged in the PubMed record.
Abstract
aimTo determine if sorafenib, an antineoplastic agent, could prevent the development of spinal epidural fibrosis (EF).
methodsThe study used CD105 and osteopontin antibodies in an immunohistochemical approach to quantify EF that occurred as a consequence of laminectomy in rats. Wistar albino rats (
resultsThe EF thickness, inflammatory cell density, and arachnoid adherences determined by light microscopy were significantly higher in the control group compared to the sorafenib-treated group. Based on fibrosis scores, the extent of EF in the treatment group was significantly lower than in the controls. Immunohistochemical staining for CD105 to identify microvessels revealed that the EF grades based on vessel count were significantly lower in the treatment group. Staining for osteopontin did not show any significant differences between the groups in terms of the extent of EF. The staging of EF based on vascular counts observed after immunohistochemical staining for CD105, but not for osteopontin, was compatible with conventional staging methods. Neither toxic effects on tissues nor systemic side effects were observed with the use of sorafenib.
conclusionLocal administration of sorafenib significantly reduced post-laminectomy EF. Decreased neovascularization in spinal tissue may be due to the sorafenib-induced inhibition of vascular endothelial growth factor.
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