Evidence map›Paper›PMID 30211029›Full record

ReviewWorld journal of nephrology2018

Unique interstitial miRNA signature drives fibrosis in a murine model of autosomal dominant polycystic kidney disease.

Ameya Patil, William E Sweeney, Cynthia G Pan, Ellis D Avner

Open access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in World journal of nephrology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Ameya PatilChildren's Research Institute; Children's' Hospital Health System of Wisconsin and the Medical College of Wisconsin, Milwaukee, WI 53226, United States. appatil@mcw.edu.
William E SweeneyChildren's Research Institute; Children's' Hospital Health System of Wisconsin and the Medical College of Wisconsin, Milwaukee, WI 53226, United States.
Cynthia G PanChildren's Research Institute; Children's' Hospital Health System of Wisconsin and the Medical College of Wisconsin, Milwaukee, WI 53226, United States.
Ellis D AvnerChildren's Research Institute; Children's' Hospital Health System of Wisconsin and the Medical College of Wisconsin, Milwaukee, WI 53226, United States.
Children's Hospital of Wisconsin · USMedical College of Wisconsin · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo delineate changes in miRNA expression localized to the peri-cystic local microenvironment (PLM) in an orthologous mouse model of autosomal dominant polycystic kidney disease (ADPKD) (

methodsWe profiled miRNA expression in the whole kidney and laser captured microdissection (LCM) samples from PLM in

resultsLCM samples revealed three temporally upregulated miRNAs [2 to 2.75-fold at PN28 and 2.5 to 4-fold (

conclusionPrecise sampling with LCM identifies miRNA changes that occur with the initiation and progression of renal interstitial fibrosis (RIF). Identification of the target proteins regulated by these miRNAs will provide new insight into the process of fibrosis and identify unique therapeutic targets to prevent or slow the development and progression of RIF in ADPKD.

Indexed as

Autosomal dominant polycystic kidney diseaseCystsEnd-stage renal diseaseInflammationmiRNARenal interstitial fibrosis

Identifiers

PMID30211029
PMCPMC6134266
OpenAlexW2891168367

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.