Evidence map›Paper›PMID 30211001›Full record

Trial reportNeuroImage. Clinical2018

The effect of physical exercise on cerebral blood flow in Alzheimer's disease.

Lisa A van der Kleij, Esben T Petersen, Hartwig R Siebner, Jeroen Hendrikse, Kristian S Frederiksen, Nanna A Sobol, Steen G Hasselbalch, Ellen Garde

Open access · goldAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in NeuroImage. Clinical, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed, 5 pooled it
6.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 5 syntheses or guidelines pooled it, 99 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 2 countries.

Lisa A van der KleijDepartment of Radiology, University Medical Center Utrecht, Utrecht, the Netherlands.
Esben T PetersenDanish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark; Center for Magnetic Resonance, DTU Elektro, Technical University of Denmark, Kgs Lyngby, Denmark.
Hartwig R SiebnerDanish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark; Department of Neurology, Copenhagen University Hospital Bispebjerg, Copenhagen, Denmark.
Jeroen HendrikseDepartment of Radiology, University Medical Center Utrecht, Utrecht, the Netherlands.
Kristian S FrederiksenDanish Dementia Research Centre, Department of Neurology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
Nanna A SobolMusculoskeletal Rehabilitation Research Unit and Institute of Sports Medicine, Copenhagen University Hospital Bispebjerg, Copenhagen, Denmark.
Steen G HasselbalchDanish Dementia Research Centre, Department of Neurology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
Ellen GardeDanish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark; Center for Healthy Aging, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. Electronic address: elga@sund.ku.dk.
Copenhagen University Hospital · DKUniversity Medical Center Utrecht · NLHvidovre Hospital · DKRigshospitalet · DKUniversity of Copenhagen · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In recent years there has been an increasing focus on the relation between cerebrovascular health, physical exercise and Alzheimer's disease. The aim of the current study was to determine the effect of moderate-to-high-intensity aerobic exercise on cerebral blood flow in patients with mild to moderate Alzheimer's disease. Fifty-one patients were randomized to either usual care or moderate-to-high intensity aerobic exercise for 16 weeks. Exercise had no consistent effect on whole brain or regional cerebral blood flow. Sixteen weeks of exercise are, therefore, not sufficient to produce a consistent increase in cerebral blood flow in a relatively small sample of Alzheimer's patients.

Indexed as

AgedAlzheimer DiseaseBrief Psychiatric Rating ScaleCerebrovascular CirculationExerciseFemaleFollow-Up StudiesHumansMaleMiddle AgedSingle-Blind MethodACC, anterior cingulate cortexAD, Alzheimer's diseaseAlzheimer's DiseaseArterial Spin labelingCBF, cerebral blood flowCerebral Blood FlowMCI, mild cognitive impairmentMMSE, Mini Mental State ExaminationMRIPCC, posterior cingulate gyrusPhysical ExerciseRandomized Controlled TrialSPG, superior parietal gyrus

Identifiers

PMID30211001
PMCPMC6129739
OpenAlexW2889962971

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.