Evidence map›Paper›PMID 30210786›Full record

ArticleF1000Research2018

Lost in translation.

Parashkev Nachev, Geraint Rees, Richard Frackowiak

Abstract read
In one paragraph

Article in F1000Research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Cognitive control & the anterior cingulate cortex: Necessity & coherence.Cortex; a journal devoted to the study of the nervous system and behavior · 2025
    Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Redefining the research hospital.NPJ digital medicine · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Parashkev NachevInstitute of Neurology, University College London, London, WC1N 3BG, UK.ORCID 0000-0002-2718-4423
Geraint ReesInstitute of Neurology, University College London, London, WC1N 3BG, UK.
Richard FrackowiakInstitute of Neurology, University College London, London, WC1N 3BG, UK.

Funding

Wellcome Trust
6 · The paper itself

Abstract

Translation in cognitive neuroscience remains beyond the horizon, brought no closer by supposed major advances in our understanding of the brain. Unless our explanatory models descend to the individual level-a cardinal requirement for any intervention-their real-world applications will always be limited. Drawing on an analysis of the informational properties of the brain, here we argue that adequate individualisation needs models of far greater dimensionality than has been usual in the field. This necessity arises from the widely distributed causality of neural systems, a consequence of the fundamentally adaptive nature of their developmental and physiological mechanisms. We discuss how recent advances in high-performance computing, combined with collections of large-scale data, enable the high-dimensional modelling we argue is critical to successful translation, and urge its adoption if the ultimate goal of impact on the lives of patients is to be achieved.

Indexed as

Models, NeurologicalBrainCausalityCognitionCognitive NeuroscienceComprehensionHumansIndividuationcausalitycognitive neurosciencehigh-dimensional inferencemachine learning.neuroimagingTranslation

Identifiers

PMID30210786
PMCPMC6107997

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.