ArticleAmerican journal of translational research2018
Identification and differentiation therapy strategy of pterygium in vitro.
Article in American journal of translational research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
1 citing paper in PubMed, 0 citations in OpenAlex.
- Differential Expression of Sox2 in Human Ocular Surface and Its Implication in Pterygium Pathogenesis.Sage open pathologyArticle
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pterygium is an invasive hyperplasia, resulting from the hyper-proliferation of epithelial cells in cornea. The aim of our present study is to identify stem cells derived from pterygiums and detect differentiation strategy of the pterygium stem cells in vitro. Fundamental properties of the cultured pterygium stem cells were mainly studied using immunofluorescence staining. While clone formation and MTT assay were utilized to evaluate the cell viability. Pterygium stem cells could be cultivated easily, expanded efficiently, but expressed multilineage stem cell markers, which could be differentiated into neuron, osteocytes and adipocytes in vitro. Pterygium-derived spheres expressed stem cell markers and the epithelial-mesenchymal transition markers after treating with the inducing assays. Proliferation and viability of pterygium stem cells could be inhibited after inducing differentiation indicating that differentiation strategy will be a promising strategy in future therapies of pterygium. Cells derived from pterygiums express multilineage stem cell markers and could be induced differentiation. Differentiation therapy strategy could inhibit pterygium stem cell in vitro.
Indexed as
Identifiers
30210698PMC6129542W2981075374What OpenQuestion holds
Registered trials
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