ArticleAmerican journal of translational research2018
Anesthesia and surgery induce delirium-like behavior in susceptible mice: the role of oxidative stress.
Article in American journal of translational research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.
- Risk prediction models for postoperative delirium in adult patients undergoing cardiac surgery: a systematic review and meta-analysis.BMC cardiovascular disorders · 2026Pooled it
- Graded surgical stress reveals postoperative behavioral changes associated with systemic oxidative stress.Scientific reports · 2026Article
- Animal models of delirium: a narrative review.Translational psychiatry · 2026Review
- Preoperative Anxiety and Postoperative Delirium: A Mini Review of the Association, Mechanisms, and Preventive Strategies.Journal of multidisciplinary healthcare · 2026Review
- The age-related susceptibility to postoperative delirium quantified by bispectral electroencephalography correlates with postoperative delirium-like behavior in mice.PCN reports : psychiatry and clinical neurosciences · 2025Article
- Article
- Lipopolysaccharide-Induced Delirium-Like Behavior and Microglial Activation in Mice Correlate With Bispectral Electroencephalography.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024Article
- Role of the circRNA_34414/miR-6960a-5p/SIRT3 axis in postoperative delirium via CA1 Vglut1+ neurons in older mice.CNS neuroscience & therapeutics · 2024Article
- Association of Hyperoxia During Cardiopulmonary Bypass and Postoperative Delirium in the Pediatric Cardiac ICU.Critical care explorations · 2024Article
- Prolonged oral intake of green tea polyphenols attenuates delirium-like behaviors in mice induced by anesthesia/surgery.Heliyon · 2024Article
- Increased A1 astrocyte activation-driven hippocampal neural network abnormality mediates delirium-like behavior in aged mice undergoing cardiac surgery.Aging cell · 2024Article
- Fish oil omega-3 Fatty Acids Alleviate Postoperative delirium-like Behavior in aged mice by Attenuating Neuroinflammation and Oxidative Stress.Neurochemical research · 2024Article
- Potential value of serum prealbumin and serum albumin in the identification of postoperative delirium in patients undergoing knee/hip replacement: an observational study and internal validation study.Frontiers in neurology · 2024Article
- The possible role of gut microbiota dysbiosis in the pathophysiology of delirium in older persons.Microbiome research reports · 2023Review
- Postoperative Delirium in Neurosurgical Patients: Recent Insights into the Pathogenesis.Brain sciences · 2022Review
- Reactive oxygen species contribute to delirium-like behavior by activating CypA/MMP9 signaling and inducing blood-brain barrier impairment in aged mice following anesthesia and surgery.Frontiers in aging neuroscience · 2022Article
- Preoperative Status of Gut Microbiota Predicts Postoperative Delirium in Patients With Gastric Cancer.Frontiers in psychiatry · 2022Article
- Phenotypes and subphenotypes of delirium: a review of current categorisations and suggestions for progression.Critical care (London, England) · 2021Review
- Ginkgolide B‑mediated therapeutic effects on perioperative neurocognitive dysfunction are associated with the inhibition of iNOS‑mediated production of NO.Molecular medicine reports · 2021Article
- Netrin-1 Ameliorates Postoperative Delirium-Like Behavior in Aged Mice by Suppressing Neuroinflammation and Restoring Impaired Blood-Brain Barrier Permeability.Frontiers in molecular neuroscience · 2021Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Anesthesia and surgery (A + S) are risk factors for patients to develop postoperative delirium (POD). However, the pathogenesis of POD remains largely to be determined. We employed battery of behavioral tests including open-filed test (OFT), elevated plus maze test (EPMT) and buried food test (BFT) to investigate the role of oxidative stress in the development of POD and to explore the therapeutic target for POD in mice after A + S (simple laparotomy under 1.4% isoflurane anesthesia). We initially found that 6 hours after A + S, mice failed to alter the behavioral changes in OFT and the adenosine triphosphate (ATP) level in hippocampus. After hierarchical cluster analysis, however, there was a significant change in the behavior tests between POD unsusceptible (non-POD) and susceptible (POD-like) mice. Interestingly, cyclosporine A, an inhibitor of mitochondrial permeability transition pore (mPTP) opening, exerted pharmacologically beneficial effects on symptoms, decreased reactive oxygen species (ROS) and ATP, and increased superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and catalase (CAT) levels in the hippocampus of POD-like mice. These findings suggest that abnormally activated oxidative stress might be involved in the underlying mechanisms of POD. Novel therapeutic agents targeting inhibition of oxidative stress would provide an available strategy for POD treatment.
Indexed as
Identifiers
30210682PMC6129548W2976592199What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.