Evidence map›Paper›PMID 30210496›Full record

ReviewFrontiers in immunology2018

T Cell/B Cell Collaboration and Autoimmunity: An Intimate Relationship.

Lina Petersone, Natalie M Edner, Vitalijs Ovcinnikovs, Frank Heuts, Ellen M Ross, Elisavet Ntavli, Chun J Wang, Lucy S K Walker

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 78 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
78citing papers in PubMed, 1 pooled it
5.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

78 citing papers in PubMed, 1 synthesis or guideline pooled it, 153 citations in OpenAlex.

  1. Guideline
  2. B cells in cancer: functions, mechanisms and therapeutic advances.Signal transduction and targeted therapy · 2026
    Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. The role of early immunotherapy in rasmussen's encephalitis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
    Article
  8. Article
  9. p38γ and p38δ support CD4Frontiers in immunology · 2026
    Article
  10. Article
  11. Review
  12. B-EPIC: A Transformer-Based Language Model for Decoding B Cell Immunodominance Patterns.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  13. Article
  14. Article
  15. The role of autoantibodies in Alzheimer's disease: Pathogenetic connections or epiphenomena?Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Review
  16. Review
  17. The immune mechanisms of the urinary tract against infections.Frontiers in cellular and infection microbiology · 2025
    Review
  18. Review
  19. Article
  20. Review

18 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Lina PetersoneDivision of Infection and Immunity, Institute of Immunity and Transplantation, University College London, London, United Kingdom.
Natalie M EdnerDivision of Infection and Immunity, Institute of Immunity and Transplantation, University College London, London, United Kingdom.
Vitalijs OvcinnikovsDivision of Infection and Immunity, Institute of Immunity and Transplantation, University College London, London, United Kingdom.
Frank HeutsDivision of Infection and Immunity, Institute of Immunity and Transplantation, University College London, London, United Kingdom.
Ellen M RossDivision of Infection and Immunity, Institute of Immunity and Transplantation, University College London, London, United Kingdom.
Elisavet NtavliDivision of Infection and Immunity, Institute of Immunity and Transplantation, University College London, London, United Kingdom.
Chun J WangDivision of Infection and Immunity, Institute of Immunity and Transplantation, University College London, London, United Kingdom.
Lucy S K WalkerDivision of Infection and Immunity, Institute of Immunity and Transplantation, University College London, London, United Kingdom.
University College London · GB

Funding

Medical Research Council MR/N001435/1
6 · The paper itself

Abstract

Co-ordinated interaction between distinct cell types is a hallmark of successful immune function. A striking example of this is the carefully orchestrated cooperation between helper T cells and B cells that occurs during the initiation and fine-tuning of T-cell dependent antibody responses. While these processes have evolved to permit rapid immune defense against infection, it is becoming increasingly clear that such interactions can also underpin the development of autoimmunity. Here we discuss a selection of cellular and molecular pathways that mediate T cell/B cell collaboration and highlight how

Indexed as

AutoimmunityAnimalsB-LymphocytesCD28 AntigensCTLA-4 AntigenGenome-Wide Association StudyGerminal CenterHumansInflammationT-Lymphocytes, Helper-InducerCD28 AntigensCTLA-4 AntigenCTLA4 protein, humanautoimmunityB cellsCD28costimulationCTLA-4follicular helper T cells (Tfh)germinal centerimmunotherapy

Identifiers

PMID30210496
PMCPMC6119692
OpenAlexW2889311601

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.