ReviewFrontiers in neural circuits2018
Causal Role of Neural Signals Transmitted From the Frontal Eye Field to the Superior Colliculus in Saccade Generation.
Review in Frontiers in neural circuits, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 25 citations in OpenAlex.
- Advanced Eye Movement Features Measured by Quantitative Oculography as Candidate Biomarkers for Progressive Supranuclear Palsy.Diagnostics (Basel, Switzerland) · 2026Review
- Role of neuronal oscillations in memory driven visual processing.BMC biology · 2026Article
- Multiple groups of neurons in the superior colliculus convert value signals into saccadic vigor.iScience · 2026Article
- Activation of SNr GABA neurons drives liver-brain-eye axis dysfunction in hepatic encephalopathy.iScience · 2026Article
- Motor Intention Drives Corticospinal Facilitation during Interception Planning.bioRxiv : the preprint server for biology · 2026Article
- Dissociable Pupil and Oculomotor Markers of Attention Allocation and Distractor Suppression during Listening.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Spatial evolution in temporal dynamics of hemodynamic response function in human superior colliculi with ultra-high-resolution MRI at 9.4T.Frontiers in neuroscience · 2026Article
- Convergent causal mapping unravels distinct frontal networks for visuospatial selective attention.Nature communications · 2025Article
- Retrograde Optogenetics Reveals Functional Convergence within a Corticotectal Pathway of Non-Human Primates.bioRxiv : the preprint server for biology · 2025Article
- Review
- A proposed attention-based model for spatial memory formation and retrieval.Cognitive processing · 2023Review
- Cortical-subcortical interactions in goal-directed behavior.Physiological reviews · 2023Review
- The Superior Colliculus: Cell Types, Connectivity, and Behavior.Neuroscience bulletin · 2022Review
- Electroencephalography Study of Frontal Lobe Evoked by Dynamic Random-Dot Stereogram.Investigative ophthalmology & visual science · 2022Article
- Altered Effective Connectivity within an Oculomotor Control Network in Unaffected Relatives of Individuals with Schizophrenia.Brain sciences · 2021Article
- Chronically implantable LED arrays for behavioral optogenetics in primates.Nature methods · 2021Article
- Altered effective connectivity within an oculomotor control network in individuals with schizophrenia.NeuroImage. Clinical · 2021Article
- Assessing the Functional Role of Frontal Eye Fields in Voluntary and Reflexive Saccades Using Continuous Theta Burst Stimulation.Frontiers in neuroscience · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The frontal eye field (FEF) and superior colliculus (SC) are major and well-studied components of the oculomotor system. The FEF sends strong projections to the SC directly, and neurons in these brain regions transmit a variety of signals related to saccadic eye movements. Electrical microstimulation and pharmacological manipulation targeting the FEF or SC affect saccadic eye movements. These data suggest the causal contribution of each region to saccade generation. To understand how the brain generates behavior, however, it is critical not only to identify the structures and functions of individual regions, but also to elucidate how they interact with each other. In this review article, we first survey previous works that aimed at investigating whether and how the FEF and SC interact to regulate saccadic eye movements using electrophysiological and pharmacological techniques. These works have reported what signals FEF neurons transmit to the SC and what roles such signals play in regulating oculomotor behavior. We then highlight a recent attempt of our own that has applied an optogenetic approach to stimulate the neural pathway from the FEF to the SC in nonhuman primates. This study has shown that optogenetic stimulation of the FEF-SC pathway is sufficiently effective not only to modulate SC neuron activity, but also to evoke saccadic eye movements. Although the oculomotor system is a complex neural network composed of numbers of cortical and subcortical regions, the optogenetic approach will provide a powerful strategy for elucidating the role of each neural pathway constituting this network.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.