Evidence map›Paper›PMID 30210279›Full record

ArticleFrontiers in neuroscience2018

How Metabolic State May Regulate Fear: Presence of Metabolic Receptors in the Fear Circuitry.

Lisa L Koorneef, Marit Bogaards, Marcel J T Reinders, Onno C Meijer, Ahmed Mahfouz

Open access · goldAbstract read
In one paragraph

Article in Frontiers in neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.8field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 13 citations in OpenAlex.

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  8. Top-down and bottom-up control of stress-coping.Journal of neuroendocrinology · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Lisa L KoorneefDivision of Endocrinology, Department of Internal Medicine, Leiden University Medical Center, Leiden University, Leiden, Netherlands.
Marit BogaardsDivision of Endocrinology, Department of Internal Medicine, Leiden University Medical Center, Leiden University, Leiden, Netherlands.
Marcel J T ReindersLeiden Computational Biology Center, Leiden University Medical Center, Leiden University, Leiden, Netherlands.
Onno C MeijerDivision of Endocrinology, Department of Internal Medicine, Leiden University Medical Center, Leiden University, Leiden, Netherlands.
Ahmed MahfouzLeiden Computational Biology Center, Leiden University Medical Center, Leiden University, Leiden, Netherlands.
Leiden University Medical Center · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Metabolic status impacts on the emotional brain to induce behavior that maintains energy balance. While hunger suppresses the fear circuitry to promote explorative food-seeking behavior, satiety or obesity may increase fear to prevent unnecessary risk-taking. Here we aimed to unravel which metabolic factors, that transfer information about the acute and the chronic metabolic status, are of primary importance to regulate fear, and to identify their sites of action within fear-related brain regions. We performed a

Indexed as

anxietyenergy balancefearfear circuitryfeedingmetabolismmonoaminesobesity

Identifiers

PMID30210279
PMCPMC6119828
OpenAlexW2888082866

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.