Evidence map›Paper›PMID 30210277›Full record

ArticleFrontiers in neuroscience2018

Targeted Sequencing of Alzheimer Disease Genes in African Americans Implicates Novel Risk Variants.

Mark W Logue, Daniel Lancour, John Farrell, Irina Simkina, M Daniele Fallin, Kathryn L Lunetta, Lindsay A Farrer

Open access · goldAbstract read
In one paragraph

Article in Frontiers in neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 5 pooled it
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 5 syntheses or guidelines pooled it, 37 citations in OpenAlex.

  1. Genetic and environmental risk factors for dementia in African adults: A systematic review.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Pooled it
  2. Pooled it
  3. Pooled it
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  5. Pooled it
  6. Trial
  7. Article
  8. Novel set of plasma proteins classifies Alzheimer's dementia in African American individuals with high accuracy.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. The ABC's of Alzheimer risk gene ABCA7.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024
    Review
  14. Towards a Unitary Hypothesis of Alzheimer's Disease Pathogenesis.Journal of Alzheimer's disease : JAD · 2024
    Article
  15. Review
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  17. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Mark W LogueNational Center for Posttraumatic Stress Disorder (PTSD), United States Department of Veterans Affairs, Boston Healthcare System, Boston, MA, United States.
Daniel LancourBiomedical Genetics, Department of Medicine, Boston University School of Medicine, Boston University, Boston, MA, United States.
John FarrellBiomedical Genetics, Department of Medicine, Boston University School of Medicine, Boston University, Boston, MA, United States.
Irina SimkinaBiomedical Genetics, Department of Medicine, Boston University School of Medicine, Boston University, Boston, MA, United States.
M Daniele FallinDepartment of Mental Health, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, United States.
Kathryn L LunettaDepartment of Biostatistics, Boston University School of Public Health, Boston University, Boston, MA, United States.
Lindsay A FarrerBiomedical Genetics, Department of Medicine, Boston University School of Medicine, Boston University, Boston, MA, United States.
Boston University · USJohns Hopkins University · USUnited States Department of Veterans Affairs · US

Funding

National Centralized Repository for Alzheimer's Disease and Related Dementias (NCRAD)U24AG021886 · NIA · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI TATIANA M. FOROUD · 2002 to 2026
$119.8M
Alzheimer's Disease Genetics ConsortiumU01AG032984 · NIA · UNIVERSITY OF PENNSYLVANIA · PI SCHELLENBERG, GERARD DAVID · 2009 to 2024
$60.4M
Neuropathology CoreP30AG013846 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI KOWALL, NEIL W. · 1996 to 2020
$29.1M
Alzheimer Disease Genetic Architecture in African AmericansR01AG048927 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI Lindsay A. Farrer · 2015 to 2026
$8.4M
Predoctoral Training in Bioinformatics and Computational BiologyT32GM100842 · NIGMS · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI TULLIUS, THOMAS D · 2012 to 2022
$2.8M
Genomic and Biological Studies of APOE ε2 in Alzheimer DiseaseRF1AG057519 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI FARRER, LINDSAY A., JUN, GYUNGAH · 2017 to 2017
$2.4M
NIA NIH HHS P30 AG013846NIA NIH HHS R01 AG048927NIA NIH HHS RF1 AG057519NIA NIH HHS U01 AG032984NIA NIH HHS U24 AG021886
6 · The paper itself

Abstract

The genetic architecture of late-onset Alzheimer disease (AD) in African Americans (AAs) differs from that in persons of European ancestry. In addition to

Indexed as

ABCA7African AmericansAKAP9Alzheimer diseaserare variantsequencing

Identifiers

PMID30210277
PMCPMC6119822
OpenAlexW2889221727

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.