Evidence map›Paper›PMID 30210223›Full record

ArticleChinese journal of cancer research = Chung-kuo yen cheng yen chiu2018

A radiomic nomogram based on an apparent diffusion coefficient map for differential diagnosis of suspicious breast findings.

Bin Hu, Ke Xu, Zheng Zhang, Ruimei Chai, Shu Li, Lina Zhang

Abstract read
In one paragraph

Article in Chinese journal of cancer research = Chung-kuo yen cheng yen chiu, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.

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14citing papers in PubMed, 2 pooled it
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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
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  3. Trial
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  5. Review
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  9. Review
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  11. Machine learning in breast MRI.Journal of magnetic resonance imaging : JMRI · 2020
    Review
  12. Article
  13. Article
  14. The Application of Radiomics in Breast MRI: A Review.Technology in cancer research & treatment
    Review
4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Bin HuDepartment of Radiology, the First Affiliated Hospital of China Medical University, Shenyang 110001, China.
Ke XuDepartment of Radiology, the First Affiliated Hospital of China Medical University, Shenyang 110001, China.
Zheng ZhangDepartment of Radiology, the First Affiliated Hospital of China Medical University, Shenyang 110001, China.
Ruimei ChaiDepartment of Radiology, the First Affiliated Hospital of China Medical University, Shenyang 110001, China.
Shu LiDepartment of Radiology, the First Affiliated Hospital of China Medical University, Shenyang 110001, China.
Lina ZhangDepartment of Radiology, the First Affiliated Hospital of China Medical University, Shenyang 110001, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo develop and validate a radiomic nomogram based on an apparent diffusion coefficient (ADC) map for differentiating benign and malignant lesions in suspicious breast findings classified as Breast Imaging Reporting and Data System (BI-RADS) category 4 on breast magnetic resonance imaging (MRI).

methodsEighty-eight patients diagnosed with BI-RADS 4 findings on breast MRI in the First Affiliated Hospital of China Medical University from December 2014 to December 2015 were retrospectively analyzed in this study. Sixty-three were randomized electronically to establish forecasting models, and the other 25 were used for validation. Radiomic features based on the ADC map were generated automatically by Artificial Intelligence Kit software (A.K. software; GE Healthcare, China). Feature reduction was conducted using the Mann-Whitney test and Spearman correlation after pre-treatment. A prediction model of ADC radiomics was established by logistic linear regression and cross-validation. A nomogram was established based on ADC radiomic features, pharmacokinetics and clinical features, including the morphology and ADC value for breast BI-RADS 4 lesions on MRI.

resultsA total of 396 radiomic features were extracted automatically by the A.K. software. Five features were selected after pre-processing, Mann-Whitney tests and Spearman correlation analysis. The area under the ROC curve of the prediction model comprising ADC radiomic features was 0.79 when the cutoff value was 0.45, and the accuracy, sensitivity and specificity were 80.0%, 0.813 and 0.778, respectively. A visualized differential nomogram based on the radiomic score, pharmacokinetics and clinical features was established. The decision curve showed good consistency.

conclusionsADC radiomic features could provide an important reference for differential diagnosis between benign and malignant lesions in suspicious BI-RADS 4 lesions. The visualized nomogram based on ADC radiomic features, pharmacokinetics and clinical features may have good prospects for clinical application.

Indexed as

ADCBI-RADS 4differential diagnosisnomogramradiomics

Identifiers

PMID30210223
PMCPMC6129569

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