ArticleJournal of atherosclerosis and thrombosis2019
Relation of Elevated Serum Uric Acid Level to Endothelial Dysfunction in Patients with Acute Coronary Syndrome.
Article in Journal of atherosclerosis and thrombosis, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.
- Uric acid is a biomarker for heart failure, but not therapeutic target: result from a comprehensive meta-analysis.ESC heart failure · 2024Pooled it
- Analysis of mortality risk and influencing factors in female patients with young-onset type 2 diabetes.Frontiers in endocrinology · 2026Article
- Antithrombin in Hyperuricemic Nephropathy: Unveiling Its Noncanonical Renoprotective Roles and Therapeutic Repurposing Potential.Kidney & blood pressure research · 2026Review
- Gout, Uric Acid, and Coronary Artery Disease.Journal of atherosclerosis and thrombosis · 2025Review
- J-shaped association of serum uric acid with all-cause and cardiovascular mortality in patients with diabetic kidney disease.Acta diabetologica · 2025Article
- Oxidative stress and inflammation mediate the adverse effects of cadmium exposure on all-cause and cause-specific mortality in patients with diabetes and prediabetes.Cardiovascular diabetology · 2025Article
- Inflammation mediates the association between hyperuricemia and stroke mortality: a cohort study.Frontiers in neurology · 2025Article
- Article
- Systemic Endothelial Function, Plasma Xanthine Oxidoreductase Activity, and Blood Pressure Variability in Patients with Stable Coronary Artery Disease.Medicina (Kaunas, Lithuania) · 2022Article
- Lowering Uric Acid May Improve Prognosis in Patients With Hyperuricemia and Heart Failure With Preserved Ejection Fraction.Journal of the American Heart Association · 2022Observational
- Association between Serum Uric Acid and Impaired Endothelial Function: The Circulatory Risk in Communities Study.Journal of atherosclerosis and thrombosis · 2022Article
- Evaluation of the prognostic ability of serum uric acid for elderly acute coronary syndrome patients with diabetes mellitus: a prospective cohort study.Journal of Zhejiang University. Science. B · 2021Article
- Impact of Serum Uric Acid Level on Systemic Endothelial Dysfunction in Patients with a Broad Spectrum of Ischemic Heart Disease.Journal of clinical medicine · 2021Article
- Greater coronary lipid core plaque assessed by near-infrared spectroscopy intravascular ultrasound in patients with elevated xanthine oxidoreductase: a mechanistic insight.Heart and vessels · 2021Observational
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimSerum uric acid (SUA) level is known to have a prognostic value in patients with acute coronary syndrome (ACS). Endothelial function plays an important role in the development of cardiovascular disease. Although relation between SUA level and endothelial function has been previously studied in various populations, it is partially understood in patients with ACS.
methodsA total of 55 patients with ACS with measurements of SUA level and reactive hyperemia index (RHI) to evaluate endothelial function were included. They were classified into three groups according to the tertiles of SUA level. The tertiles of SUA level were as follows: low tertile, ≤ 5.2 mg/dl; intermediate tertile, 5.3 to 6.5 mg/dl; and high tertile, ≥ 6.6 mg/dl.
resultsMean SUA level and RHI were 5.8±1.5 mg/dl and 1.88±0.58. There was a significant negative correlation between SUA level and RHI (r=-0.41, p=0.002). RHI was stepwisely observed in favor of the higher tertile groups (2.14±0.74 vs. 1.84±0.45 vs. 1.67±0.38, p=0.04). Multivariate analysis showed elevated SUA level as an independent predictor of reduced RHI.
conclusionElevated SUA level was significantly associated with endothelial dysfunction in patients with ACS, possibly leading to subsequent poor outcomes following ACS.
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