Evidence map›Paper›PMID 30209758›Full record

ArticleDaru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences2018

Proliferation and In Vitro Wound Healing Effects of the Microniosomes Containing Narcissus tazetta L. Bulb Extract on Primary Human Fibroblasts (HDFs).

Maryam Rameshk, Fariba Sharififar, Mitra Mehrabani, Abbas Pardakhty, Alireza Farsinejad, Mehrnaz Mehrabani

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.

  1. A critical overview of challenging roles of medicinal plants in improvement of wound healing technology.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Maryam RameshkHerbal and Traditional Medicines Research Center, Department of Pharmacognosy, Faculty of Pharmacy Kerman University of Medical Sciences, Haft Bagh-e Alavi Blvd, Kerman, Iran.
Fariba SharififarHerbal and Traditional Medicines Research Center, Department of Pharmacognosy, Faculty of Pharmacy Kerman University of Medical Sciences, Haft Bagh-e Alavi Blvd, Kerman, Iran.
Mitra MehrabaniHerbal and Traditional Medicines Research Center, Department of Pharmacognosy, Faculty of Pharmacy Kerman University of Medical Sciences, Haft Bagh-e Alavi Blvd, Kerman, Iran.
Abbas PardakhtyPharmaceutics Research Center, Neuropharmacology Institute, Kerman University of Medical Sciences, Haft Bagh-e Alavi Blvd, Kerman, Iran. abpardakhty@kmu.ac.ir.
Alireza FarsinejadDepartment of Hematology and Blood Banking, faculty of allied Medical Sciences, Kerman University of Medical Sciences, Kerman, Iran.
Mehrnaz MehrabaniPhysiology Research Center; Neuropharmacology Institute, Kerman University of Medical Sciences, Ibne cina street, Kerman, Iran.
Kerman University of Medical Sciences · IRShahid Bahonar University of Kerman · IR

Funding

Deputy of Research of Kerman University of Medical Sciences 94/584
6 · The paper itself

Abstract

purposeIn Traditional Persian Medicine (TPM), different natural treatments have been suggested for skin damages such as Narcissus tazetta L. bulb application. New drug delivery systems such as niosomes have shown considerable increase transdermal drug delivery through stratum corneum, the main barrier against substances transport into skin. The aim of this study is preparation of niosomal formulations from N. tazetta bulb extract and evaluation of its in vitro wound healing effect. MATERIALS AND

methodsNon-ionic surfactant vesicles (NSVs or niosomes) were prepared by film hydration method from percolated extract of N. tazetta bulb. A number of 12 niosomal formulations (F1-F12) were prepared using different proportions of Span 60/Tween 60/cholesterol and 80% methanol-dissolved/aqueous PEN (percolation extract of N. tazetta) (30 and 50 mg/ml). Their morphology, particle size, physical and chemical stability and encapsulation efficiency was studied. In vitro wound healing effect of various concentrations of the best PEN niosomal formulation (F9) was evaluated in comparison to PEN on human dermal fibroblasts (HDFs).

resultsIncreasing the aqueous/methanolic PEN concentration from 3 to 5% resulted size reduction of NSVs with statistically significant difference (p < 0.05). F9 showed the most physicochemical stability and was chosen for in vitro wound healing effect. This formulation exhibited significantly effects (p < 0.05) on cell proliferation in HDF cells at 1.562 and 3.125 μg/ml compared with the untreated cells using neutral red assay.

conclusionFormulation of PEN in niosome carrier significantly decreased the gap width on human dermal fibroblasts. Graphical abstract Schematic processes of proliferation effect of narcisus tazetta bulb on fibroblast cells.

Indexed as

Human dermal fibroblastNarcissus tazettaNiosomeTraditional Persian medicineWound healing

Identifiers

PMID30209758
PMCPMC6154482
OpenAlexW2891814472

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.