Evidence map›Paper›PMID 30209754›Full record

ArticleJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology2020

Diagnostic performance of an artificial intelligence-driven cardiac-structured reporting system for myocardial perfusion SPECT imaging.

Ernest V Garcia, J Larry Klein, Valeria Moncayo, C David Cooke, Christian Del'Aune, Russell Folks, Liudmila Verdes Moreiras, Fabio Esteves

Open access · greenAbstract read
In one paragraph

Article in Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
3.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 38 citations in OpenAlex.

  1. Review
  2. Article
  3. Artificial Intelligence in Nuclear Cardiology.Journal of clinical medicine · 2025
    Review
  4. Article
  5. Review
  6. Review
  7. Quantitation of diffuse myocardial ischemia with mental stress and its association with cardiovascular events in individuals with recent myocardial infarction.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023
    Article
  8. Diagnosis of diffuse ischemia with SPECT relative perfusion imaging: How to eat soup with a fork?Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023
    Article
  9. Integrating artificial intelligence and natural language processing for computer-assisted reporting and report understanding in nuclear cardiology.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023
    Review
  10. Review
  11. "Global" cardiac atherosclerotic burden assessed by artificial intelligence-based versus manual segmentation inJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2022
    Article
  12. Artificial intelligence in nuclear cardiology: Preparing for the fifth industrial revolution.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021
    Article
  13. Early onset of left ventricular regional asynchrony in arteries with sub-clinical stenosis.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021
    Article
  14. Review
  15. Quantitative clinical nuclear cardiology, part 2: Evolving/emerging applications.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021
    Review
  16. Review
  17. Leveraging latest computer science tools to advance nuclear cardiology.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2019
    Article
  18. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Ernest V GarciaDepartment of Radiology and Imaging Sciences, Emory University, 101 Woodruff Circle, Room 1203, Atlanta, GA, 30322, USA. ernest.garcia@emory.edu.
J Larry KleinDivision of Cardiology, Department of Medicine, UNC School of Medicine, University of North Carolina, Chapel Hill, NC, USA.
Valeria MoncayoDepartment of Radiology and Imaging Sciences, Emory University, 101 Woodruff Circle, Room 1203, Atlanta, GA, 30322, USA.
C David CookeDepartment of Radiology and Imaging Sciences, Emory University, 101 Woodruff Circle, Room 1203, Atlanta, GA, 30322, USA.
Christian Del'AuneSyntermed, Inc., Atlanta, GA, USA.
Russell FolksDepartment of Radiology and Imaging Sciences, Emory University, 101 Woodruff Circle, Room 1203, Atlanta, GA, 30322, USA.
Liudmila Verdes MoreirasDepartment of Radiology and Imaging Sciences, Emory University, 101 Woodruff Circle, Room 1203, Atlanta, GA, 30322, USA.
Fabio EstevesDepartment of Radiology and Imaging Sciences, Emory University, 101 Woodruff Circle, Room 1203, Atlanta, GA, 30322, USA.
Emory University · USSyntermed (United States) · USUniversity of North Carolina at Chapel Hill · US

Funding

Novel WEB Decision Support System for cardiac image interpretation and reportingR42HL106818 · NHLBI · SYNTERMED, INC, · PI GARCIA, ERNEST V, VAN TRAIN, KENNETH · 2011 to 2013
$2.3M
NHLBI NIH HHS R42 HL106818
6 · The paper itself

Abstract

objectivesTo describe and validate an artificial intelligence (AI)-driven structured reporting system by direct comparison of automatically generated reports to results from actual clinical reports generated by nuclear cardiology experts.

backgroundQuantitative parameters extracted from myocardial perfusion imaging (MPI) studies are used by our AI reporting system to generate automatically a guideline-compliant structured report (sR).

methodA new nonparametric approach generates distribution functions of rest and stress, perfusion, and thickening, for each of 17 left ventricle segments that are then transformed to certainty factors (CFs) that a segment is hypoperfused, ischemic. These CFs are then input to our set of heuristic rules used to reach diagnostic findings and impressions propagated into a sR referred as an AI-driven structured report (AIsR). The diagnostic accuracy of the AIsR for detecting coronary artery disease (CAD) and ischemia was tested in 1,000 patients who had undergone rest/stress SPECT MPI.

resultsAt the high-specificity (SP) level, in a subset of 100 patients, there were no statistical differences in the agreements between the AIsr, and nine experts' impressions of CAD (P = .33) or ischemia (P = .37). This high-SP level also yielded the highest accuracy across global and regional results in the 1,000 patients. These accuracies were statistically significantly better than the other two levels [sensitivity (SN)/SP tradeoff, high SN] across all comparisons.

conclusionsThis AI reporting system automatically generates a structured natural language report with a diagnostic performance comparable to those of experts.

Indexed as

Artificial IntelligenceDiagnosis, Computer-AssistedMyocardial Perfusion ImagingTomography, Emission-Computed, Single-PhotonAgedCoronary Artery DiseaseFemaleHumansMaleMiddle AgedObserver VariationRetrospective StudiesSensitivity and Specificityartificial intelligenceExpert systemsmyocardial perfusion SPECTquantitative analysis, structured reporting

Identifiers

PMID30209754
PMCPMC6414293
OpenAlexW2891106826

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.