Evidence map›Paper›PMID 30209717›Full record

ArticleJournal of mammary gland biology and neoplasia2019

A Transgenic MMTV-Flippase Mouse Line for Molecular Engineering in Mammary Gland and Breast Cancer Mouse Models.

Fabiana Lüönd, Ruben Bill, Andrea Vettiger, Heide Oller, Pawel Pelczar, Gerhard Christofori

Abstract read
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In one paragraph

Article in Journal of mammary gland biology and neoplasia, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

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  2. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Fabiana LüöndDepartment of Biomedicine, University of Basel, Mattenstrasse 28, 4058, Basel, Switzerland.
Ruben BillDepartment of Biomedicine, University of Basel, Mattenstrasse 28, 4058, Basel, Switzerland.
Andrea VettigerDepartment of Biomedicine, University of Basel, Mattenstrasse 28, 4058, Basel, Switzerland.
Heide OllerCenter for Transgenic Models, University of Basel, Mattenstrasse 22, 4058, Basel, Switzerland.
Pawel PelczarCenter for Transgenic Models, University of Basel, Mattenstrasse 22, 4058, Basel, Switzerland.
Gerhard ChristoforiDepartment of Biomedicine, University of Basel, Mattenstrasse 28, 4058, Basel, Switzerland. gerhard.christofori@unibas.ch.
University of Basel · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Genetically engineered mouse models have become an indispensable tool for breast cancer research. Combination of multiple site-specific recombination systems such as Cre/loxP and Flippase (Flp)/Frt allows for engineering of sophisticated, multi-layered conditional mouse models. Here, we report the generation and characterization of a novel transgenic mouse line expressing a mouse codon-optimized Flp under the control of the mouse mammary tumor virus (MMTV) promoter. These mice show robust Flp-mediated recombination in luminal mammary gland and breast cancer cells but no Flp activity in non-mammary tissues, with the exception of limited activity in salivary glands. These mice provide a unique tool for studying mammary gland biology and carcinogenesis in mice.

Indexed as

AnimalsCarcinogenesisDisease ProgressionDNA NucleotidyltransferasesEpithelial CellsFemaleGenes, ReporterGenetic VectorsLuminescent ProteinsMammary Glands, AnimalMammary Neoplasms, ExperimentalMammary Tumor Virus, MouseMiceMice, TransgenicMicroinjectionsPromoter Regions, GeneticDNA NucleotidyltransferasesFLP recombinaseLuminescent ProteinsRed Fluorescent ProteinBreast cancerFlippaseLineage tracingMammary glandMMTV promoterTransgenic mice

Identifiers

PMID30209717
OpenAlexW2889674626

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.