Evidence map›Paper›PMID 30209706›Full record

ArticleAnnals of biomedical engineering2019

Reduction of Pressure Gradient and Turbulence Using Vortex Generators in Prosthetic Heart Valves.

Hoda Hatoum, Lakshmi P Dasi

Abstract read
In one paragraph

Article in Annals of biomedical engineering, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Atrial and ventricular flows across a transcatheter mitral valve.Interactive cardiovascular and thoracic surgery · 2021
    Article
  8. The hemodynamics of transcatheter aortic valves in transcatheter aortic valves.The Journal of thoracic and cardiovascular surgery · 2021
    Article
  9. Impact of superhydrophobicity on the fluid dynamics of a bileaflet mechanical heart valve.Journal of the mechanical behavior of biomedical materials · 2020
    Article
  10. Article
  11. Article
  12. In-vitro characterization of self-expandable textile transcatheter aortic valves.Journal of the mechanical behavior of biomedical materials · 2020
    Article
  13. A turbulence in vitro assessment of On-X and St Jude Medical prostheses.The Journal of thoracic and cardiovascular surgery · 2020
    Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Hoda HatoumDepartment of Biomedical Engineering, The Ohio State University, 473W 12th Ave., Columbus, OH, 43210, USA.
Lakshmi P DasiDepartment of Biomedical Engineering, The Ohio State University, 473W 12th Ave., Columbus, OH, 43210, USA. lakshmi.dasi@osumc.edu.

Funding

Superhydrophobic Heart Valve ProsthesisR01HL135505 · NHLBI · OHIO STATE UNIVERSITY · PI DASI, LAKSHMI PRASAD, KOTA, ARUN KUMAR · 2017 to 2020
$2.9M
Hyaluronan enhanced polymeric heart valve prosthesisR01HL119824 · NHLBI · OHIO STATE UNIVERSITY · PI DASI, LAKSHMI PRASAD · 2013 to 2017
$1.7M
Superomniphobic flow controlled prosthetic heart valveR21HL139208 · NHLBI · OHIO STATE UNIVERSITY · PI DASI, LAKSHMI PRASAD, KOTA, ARUN KUMAR · 2018 to 2019
$408k
National Institutes of Health R01HL119824National Institutes of Health R01HL135505NHLBI NIH HHS R01 HL119824NHLBI NIH HHS R01 HL135505NHLBI NIH HHS R21 HL139208
6 · The paper itself

Abstract

Blood damage and platelet activation are inherent problems with present day bi-leaflet mechanical heart valve designs. Passive flow control through different arrangements of vortex generators (VG) as means of improving pressure gradients and reducing turbulence are investigated. Rectangular VG arrays were mounted on the downstream surfaces of a 23 mm 3D printed mechanical valve. The effect of VGs on the resulting flow structures were assessed under pulsatile physiological flow conditions where high resolution particle image velocimetry measurement was performed. The co-rotating VGs showed lower Reynolds shear stresses and improved pressure gradients (PG) compared with the counter-rotating ones and the no-VG control one (that showed higher turbulence). RSS was found 38.13 ± 0.89, 12.95 ± 0.32, 15.75 ± 0.71, 24.54 ± 0.84 and 16.33 ± 0.58 Pa for the control, co-rotating VGs, 8 counter-rotating VGs, 4 far-spaced VGs and 4 closely-spaced VGs, respectively. PG of 10.45 ± 0.94 mmHg was obtained with co-rotating VGs and the difference was significant compared with the other configurations (control 14.88 ± 0.4 mmHg; 8 counter-rotating VGs 13.76 ± 0.51 mmHg; 4 far-spaced VGs 13.84 ± 0.09 mmHg; and 4 closely-spaced VGs 15.37 ± 0.16 mmHg). Co-rotating VGs for this application induce a more delayed flow separation and a more homogenized and streamlined transition of flow compared with the counter-rotating VGs. Passive flow control techniques deployed on BHMVs is potentially beneficial as significant control of flow at small length scales without inducing large-scale design modifications of the valve.

Indexed as

Heart Valve ProsthesisPressurePulsatile FlowRheologyStress, MechanicalAnti-coagulantBi-leaflet mechanical valvesBlood damageCo-rotatingCounter-rotatingFlow separationReynold’s shear stressVortex generators

Identifiers

PMID30209706
PMCPMC6408289

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.