ArticleClinical autonomic research : official journal of the Clinical Autonomic Research Society2019
Autonomic symptom burden is an independent contributor to multiple sclerosis related fatigue.
Article in Clinical autonomic research : official journal of the Clinical Autonomic Research Society, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 26 citations in OpenAlex.
- Functional Connectivity Alterations of the Central Autonomic Network in Multiple Sclerosis: Links to Fatigue and Aerobic Training Effects.Neurology(R) neuroimmunology & neuroinflammation · 2026Article
- Article
- Exploring Factors Associated with Falls in Multiple Sclerosis: Insights from a Scoping Review.Clinical interventions in aging · 2024Article
- A complex interplay between autonomic symptoms and symptoms of depression, anxiety, and stress.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2023Article
- Heart rate variability and fatigue in MS: two parallel pathways representing disseminated inflammatory processes?Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2023Review
- Brain Structural and Functional Alterations in Multiple Sclerosis-Related Fatigue: A Systematic Review.Neurology international · 2022Review
- The Link Between Energy-Related Sensations and Metabolism: Implications for Treating Fatigue.Frontiers in psychology · 2022Review
- Unveiling the relationship between autonomic involvement, fatigue, and cognitive dysfunction in early relapsing-remitting multiple sclerosis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2021Article
- Cardiac autonomic function in patients with early multiple sclerosis.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2021Article
- Cardiac Autonomic Dysfunction in Multiple Sclerosis: A Systematic Review of Current Knowledge and Impact of Immunotherapies.Journal of clinical medicine · 2020Review
- Cardiovascular Autonomic Dysfunction and Falls in People With Multiple Sclerosis: Is There a Link? An Opinion Article.Frontiers in neuroscience · 2020Article
- Autonomic nervous system dysfunction and fatigue in multiple sclerosis: common pathophysiology or spurious association?Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2019Article
- Fatigue in Parkinson's Disease Associates with Lower Ambulatory Diastolic Blood Pressure.Journal of Parkinson's disease · 2019Article
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Authors and funding
12 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo investigate a possible association between autonomic dysfunction and fatigue in people with multiple sclerosis.
methodsIn 70 people with multiple sclerosis early in the disease course (51 females, mean age 33.8 ± 9.1), quantitative sudomotor axon reflex tests, cardiovascular reflex tests (heart rate and blood pressure responses to the Valsalva maneuver and heart rate response to deep breathing), and the tilt table test were performed. Participants completed the Composite Autonomic Symptom Score 31, the Modified Fatigue Impact Scale, and the Epworth Sleepiness Scale, as well as the Beck Depression Inventory. Cutoff scores of ≥ 38 or ≥ 45 on the Modified Fatigue Impact Scale were used to stratify patients into a fatigued subgroup (N = 17 or N = 9, respectively).
resultsWe found clear associations between fatigue and scores in subjective tests of the autonomic nervous system: fatigued patients scored significantly worse on Composite Autonomic Symptom Score 31, and there was a strong correlation between the Modified Fatigue Impact Scale and the Composite Autonomic Symptom Score 31 (r
conclusionThese results suggest that-even early in the course of the disease-people with multiple sclerosis suffer from objective and subjective impairments of the autonomic nervous system. The results also point to an association between autonomic nervous system impairment and multiple sclerosis related fatigue.
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