Observational studyJournal of neurology2018
Quality of life in a German cohort of Parkinson's patients assessed with three different measures.
Observational study in Journal of neurology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 3 syntheses or guidelines pooled it, 29 citations in OpenAlex.
- Health-related quality of life in Parkinson's disease: systematic review and meta-analysis of EuroQol (EQ-5D) utility scores.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2024Pooled it
- Quality of life in Parkinson's disease: A systematic review and meta-analysis of comparative studies.CNS neuroscience & therapeutics · 2021Pooled it
- [Inpatient treatment costs, cost-driving factors and potential reimbursement problems due to fall-related fractures in patients with Parkinson's disease].Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen · 2020Pooled it
- The inertial-based gait normalcy index of dual task cost during turning quantifies gait automaticity improvement in early-stage Parkinson's rehabilitation.Journal of neuroengineering and rehabilitation · 2024Trial
- Sex Differences in Motor Unit Behavior in Patients With Parkinson's Disease.The European journal of neuroscience · 2025Article
- Moving toward wellbeing: physical activity and quality of life in individuals with physical disabilities in Saudi Arabia.Frontiers in psychology · 2025Article
- Factors associated with self-rated health in people with late-stage parkinson's and cognitive impairment.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2024Article
- Severity of depressive and motor symptoms impacts quality of life in Parkinson's disease patients at an academic movement clinic: A cross-sectional study.Clinical parkinsonism & related disorders · 2023Article
- Myeloperoxidase and Advanced Oxidation Protein Products in the Cerebrospinal Fluid in Women and Men with Parkinson's Disease.Antioxidants (Basel, Switzerland) · 2022Article
- Association between new-onset Parkinson's disease and suicide risk in South Korea: a nationwide cohort study.BMC psychiatry · 2022Article
- Influence of motor impairment on exercise capacity and quality of life in patients with Parkinson disease.Journal of exercise rehabilitation · 2021Article
- Relationship Satisfaction in People with Parkinson's Disease and Their Caregivers: A Cross-Sectional Observational Study.Brain sciences · 2021Article
- One Year Trajectory of Caregiver Burden in Parkinson's Disease and Analysis of Gender-Specific Aspects.Brain sciences · 2021Article
- Effect of glucocorticoids infiltration on CRSwNP after endoscopic sinus surgery and the curative efficacy of nasal ventilation function and mucociliary clearance.American journal of translational research · 2021Article
- Gender Differences and Quality of Life in Parkinson's Disease.International journal of environmental research and public health · 2020Review
- A Wearable System to Objectify Assessment of Motor Tasks for Supporting Parkinson's Disease Diagnosis.Sensors (Basel, Switzerland) · 2020Article
- Parkinson's Disease in Women and Men: What's the Difference?Journal of Parkinson's disease · 2019Review
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundParkinson's disease (PD) is characterized by severe motor and non-motor symptoms reducing patients' quality of life (QoL). Instruments have been well established for QoL assessments in PD, including the EuroQol (EQ-5D), the Parkinson's disease questionnaire (PDQ-39), or rather uncommon, like the WHOQOL-100. So far, the impact of variables has been investigated for each of these measures separately in different study populations, limiting the comparability of the results. Thus, this study compared the EQ-5D, PDQ-39, and the WHOQOL-100 (with its short-form WHOQOL-BREF) in the same study population.
methodsSeventy-five PD outpatients were assessed in a prospective study, including disease severity according to Hoehn and Yahr stage (HY) and Unified Parkinson Disease Rating Scale (UPDRS). The Geriatric Depression Scale (GDS-15) screened for depression.
resultsDecreased QoL was found with all three instruments. In multivariate models, sex and treatment complications had an impact on QoL according to all three measures, while duration of PD and HY was not associated with QoL in any of them. Depression was relevant for the WHOQOL-100/WHOQOL-BREF and the PDQ-39, but not for the EQ-5D. The total variances explained by the WHOQOL-100, WHOQOL-BREF, PDQ-39, and the EQ-5D were 0.27, 0.34, 0.70, and 0.50, respectively.
conclusionsThe associations between clinical aspects of PD and QoL vary substantially among all three measures. Importantly, depression as a frequent comorbidity in PD is underestimated by the EQ-5D, but not by the PDQ-39 and the WHOQOL-100/WHOQOL-BREF. In turn, motor impairments are underestimated by the latter and associated strongest with QoL in the EQ-5D.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.